Tecfidera (Dimethyl Fumarate)

Tecfidera
Dimethyl Fumarate

Source:
Source:
Tecfidera
Dimethyl Fumarate

Source:
Source:

Tecfidera (Dimethyl Fumarate)

Tecfidera (Dimethyl Fumarate)

Tecfidera (Dimethyl Fumarate) is an oral medication designed for the treatment of relapsing forms of multiple sclerosis (MS). This innovative treatment works by reducing inflammation and protecting nerve cells, helping to manage symptoms and reduce the frequency of relapses. Tecfidera offers a convenient twice-daily dosing schedule, providing a practical solution for individuals seeking to manage their MS effectively.

Why Choose Tecfidera (Dimethyl Fumarate)?

  • Reduces MS Relapses: Tecfidera has been shown to significantly decrease the number of relapses in patients with relapsing forms of multiple sclerosis.
  • Slows Disease Progression: Helps in slowing down the progression of physical disability associated with MS.
  • Convenient Oral Administration: Easy-to-take capsule form, administered twice daily.
  • Neuroprotective Properties: Protects nerve cells from damage by modulating the immune response.
  • Proven Efficacy: Supported by clinical trials demonstrating its effectiveness in managing MS symptoms and progression.

How to Use Tecfidera (Dimethyl Fumarate)?

  • Consult Your Healthcare Provider: Before starting Tecfidera, discuss your medical history and any other medications you are taking with your doctor.
  • Follow Dosage Instructions: Take the medication exactly as prescribed by your healthcare provider. Typically, Tecfidera is taken twice daily with food to reduce the likelihood of gastrointestinal side effects.
  • Swallow Whole: Do not crush, chew, or sprinkle the contents of the capsule.
  • Regular Monitoring: Schedule regular check-ups with your doctor to monitor your response to the treatment and adjust dosages if necessary.
  • Report Side Effects: Inform your healthcare provider about any side effects or adverse reactions you experience.

Important Safety Information about Tecfidera

  • Allergic Reactions: Seek immediate medical attention if you experience symptoms of a severe allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing.
  • Infections: Tecfidera may lower your white blood cell count, potentially increasing the risk of infections. Inform your doctor if you develop any signs of infection, such as fever, chills, or persistent sore throat.
  • Liver Function: Periodic liver function tests may be recommended, as Tecfidera can affect liver enzymes.
  • Flushing: Some patients may experience flushing (redness, warmth, itching, or burning sensation). This is usually mild to moderate and often decreases over time.

Fact Table

 

Facts Details
Brand Name Tecfidera
Generic Name Dimethyl Fumarate
Drug Class Disease-modifying therapy (DMT) for Multiple Sclerosis
Indication Treatment of relapsing forms of multiple sclerosis (MS)
Mechanism of Action Reduces inflammation and prevents immune cells from attacking nerves by activating the Nrf2 pathway
Dosage Form Oral capsules
Strengths Available 120 mg and 240 mg capsules
Usual Dosage – Initial: 120 mg twice daily for 7 days – Maintenance: 240 mg twice daily
Administration Taken orally, with or without food; taking with food may reduce gastrointestinal side effects
Key Benefits – Reduces frequency of MS relapses – Slows progression of physical disability – Oral administration provides convenience
Common Side Effects – Flushing – Abdominal pain – Diarrhea – Nausea – Upper respiratory tract infections
Contraindications Known hypersensitivity to dimethyl fumarate or any of the excipients in Tecfidera
Special Precautions – Monitor liver function tests – Regular blood tests to check lymphocyte counts – Caution in patients with a history of severe infection
Drug Interactions Avoid use with other immunomodulating therapies and live vaccines
Pregnancy Category Category C (Risk cannot be ruled out; use only if benefits justify the potential risks)
Storage Store at room temperature (20°C to 25°C or 68°F to 77°F)
Approval Date Approved by FDA in March 2013

Common Side Effects

Like all medications, Tecfidera (Dimethyl Fumarate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Flushing
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Upper respiratory tract infections

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Tecfidera (Dimethyl Fumarate)?

You can order Tecfidera (Dimethyl Fumarate) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. Is Tecfidera safe to use during pregnancy or breastfeeding?

    Tecfidera should only be used during pregnancy if clearly needed, as the effects on the unborn baby are not fully known. It is also unknown if Tecfidera passes into breast milk, so consult your doctor before breastfeeding while on this medication.

  2. Does Tecfidera interact with other medications?

    Tecfidera may interact with other drugs that affect the immune system or increase infection risk, such as natalizumab or rituximab. Always inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.

  3. Can I stop taking Tecfidera abruptly?

    Unlike some other MS medications, stopping Tecfidera abruptly does not typically lead to rebound disease activity. However, any decision to stop or change medication should be made in consultation with your healthcare provider.

  4. How long does it take for Tecfidera to start working?

    Tecfidera may start to show effects within 24 weeks, but it can take up to two years to experience the full benefits. It’s important to continue taking the medication as prescribed, even if you do not notice immediate improvements.

  5. Can I drink alcohol while taking Tecfidera?

    Though alcohol does not interact directly with Tecfidera, avoiding heavy alcohol consumption is advised because it may elevate the risk of stomach irritation or other side effects. Drinking alcohol in moderation, with some time between your Tecfidera dose and alcohol intake, is generally considered safe.

  6. Can Tecfidera cause weight changes?

    While weight gain or loss is not a commonly documented side effect of Tecfidera, some patients have reported weight fluctuations. It’s important to monitor any significant changes and discuss them with your doctor.

  7. What are the common side effects of Tecfidera?

    Common side effects include flushing, redness, itching, or a burning sensation on the skin, as well as stomach pain, nausea, vomiting, diarrhea, and indigestion. Should you experience any adverse effects, promptly contact your physician.

  8. How does Tecfidera work?

    Tecfidera is believed to work by reducing inflammation and preventing nerve damage in the brain and spinal cord. Although the exact mechanism is not fully understood, it is thought to involve modulation of the immune system to decrease the activity of MS.

  9. What is Tecfidera used for?

    Tecfidera is used to treat relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It helps reduce the frequency of flare-ups and slow the progression of physical disability.

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References
Tecfidera (Dimethyl Fumarate) [package insert].Cambridge, MA: Biogen; 2017.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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