Pradaxa (Dabigatran Etexilate Mesilate)
Pradaxa (Dabigatran Etexilate Mesilate)
Pradaxa (Dabigatran Etexilate Mesilate) is a groundbreaking anticoagulant medication that provides a reliable alternative to warfarin for patients requiring blood thinning to prevent strokes and blood clots. Unlike warfarin, Pradaxa does not require regular blood monitoring, offering convenience and peace of mind. Developed with patient safety in mind, Pradaxa is a testament to advancements in medical science, offering effective protection against the risks of stroke and systemic embolism in patients with non-valvular atrial fibrillation.
Why Choose Pradaxa (Dabigatran Etexilate Mesilate)?
- Reduced Stroke Risk: Significantly lowers the risk of stroke and blood clots in patients with non-valvular atrial fibrillation.
- No Regular Blood Monitoring: Simplifies treatment routines by eliminating the need for frequent INR testing, which is necessary with warfarin.
- Dose Precision: Comes in fixed doses, allowing for a straightforward medication regimen without the constant adjustments often required by warfarin.
- Reversible Anticoagulation: In case of bleeding or emergency surgery, the effects of Pradaxa can be reversed with a specific antidote, offering an additional layer of safety.
How to Use Pradaxa (Dabigatran Etexilate Mesilate)?
- Consult Your Doctor: Before starting Pradaxa, have a detailed discussion with your healthcare provider about your medical history, current health conditions, and any other medications or supplements you’re taking.
- Prescription Details: Your doctor will prescribe the appropriate dosage based on your health condition, age, and treatment goals. It’s crucial to follow this prescription precisely.
- Dosage: Take Pradaxa exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Pradaxa without talking to your doctor.
- Administration: Swallow Pradaxa capsules whole with a glass of water. Do not break, chew, or open the capsules as this can affect the medication’s effectiveness.
- With or Without Food: Pradaxa can be taken with or without food. Follow your doctor’s instructions or the guidance provided on the medication label.
- Timing: If you take Pradaxa twice a day, try to space your doses about 12 hours apart to maintain an even level of medication in your blood.
Important Safety Information about Pradaxa
- Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses simultaneously to make up for a missed dose.
- Storage: Store Pradaxa at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.
- Disposal: If you need to dispose of Pradaxa, ask your pharmacist or healthcare provider about the proper disposal method. Do not dispose of medications in wastewater or household waste.
- Surgery and Dental Procedures: Inform your doctor or dentist that you are taking Pradaxa if you plan to have any surgery or dental procedures. You may need to stop taking Pradaxa for a short time.
Fact Table
| Facts | Details |
| Generic Name | Dabigatran Etexilate Mesilate |
| Brand Name | Pradaxa |
| Drug Class | Direct Thrombin Inhibitor |
| FDA Approval | Approved by the FDA for use in the United States. (For specific approval dates, refer to the FDA website or Pradaxa’s packaging as approval dates may vary by country.) |
| Indications | – Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. – Treatment and prevention of deep vein thrombosis and pulmonary embolism. |
| Dosage Forms | Oral capsules are available in multiple strengths (e.g., 75 mg, 110 mg, 150 mg). |
| Administration | Taken orally, with or without food. Capsules should be swallowed whole. |
| Dosage | Dosage varies based on indication, patient age, renal function, and risk factors. Consult a healthcare provider for individual recommendations. |
| Key Benefits | – Does not require regular blood monitoring.- Fixed dosing without the need for frequent adjustments.- Has a specific antidote for reversal (idarucizumab) in case of emergency bleeding. |
| Common Side Effects | – Bleeding complications (e.g., gastrointestinal bleeding, minor bleeding like nosebleeds).- Stomach pain, indigestion, nausea. |
| Storage Instructions | Store at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use. |
| Special Precautions | – The risk of bleeding increases with age.- Not recommended for patients with mechanical heart valves.- Careful with surgeries or dental procedures; may need to stop Pradaxa temporarily. |
| Interactions | May interact with other anticoagulants, antiplatelet agents, and certain medications affecting renal function or blood clotting processes. Consult a healthcare provider for a complete list. |
| Pregnancy Category | Consult with a healthcare provider as Pradaxa may pose risks during pregnancy and breastfeeding. |
| Mechanism of Action | Inhibits thrombin, preventing the conversion of fibrinogen to fibrin, thus reducing the formation of blood clots. |
Common Side Effects
Like all medications, Pradaxa (Dabigatran Etexilate Mesilate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Easy bruising
- Minor bleeding
- Nosebleeds
- Gastrointestinal symptoms
- Heartburn
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Pradaxa (Dabigatran Etexilate Mesilate)?
You can order Pradaxa (Dabigatran Etexilate Mesilate) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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