Ibrance (Palbociclib)

 

Ibrance (Palbociclib)

Ibrance (palbociclib) is a prescription medication used to treat certain types of breast cancer. It is specifically designed for postmenopausal women and men with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Ibrance is typically used in combination with an aromatase inhibitor or fulvestrant as part of a first-line treatment.

Why Choose Ibrance (Palbociclib)?

• Targets Specific Pathways: Ibrance works by inhibiting cyclin-dependent kinases (CDK) 4 and 6, which are enzymes that help control the growth and division of cells. By blocking these pathways, Ibrance helps slow the progression of cancer.
• Enhances Hormonal Therapy: When used in combination with hormonal therapies, Ibrance has been shown to significantly delay disease progression compared to hormonal therapy alone.
• Oral Administration: Taken orally, Ibrance offers a convenient form of treatment that can be administered at home.

How to Use Ibrance (Palbociclib)?

• Dosage: Ibrance is available in capsule form in 75 mg, 100 mg, and 125 mg doses. The recommended starting dose is 125 mg taken once daily for 21 consecutive days followed by 7 days of treatment to complete a 28-day cycle.
• Administration: Take the capsules at the same time each day, with or without food.
• Treatment Duration: Continue taking Ibrance as directed by your healthcare provider, typically until disease progression or unacceptable toxicity.

Important Safety Information about Ibrance

• Blood Cell Counts: Ibrance can result in severe neutropenia, which can lead to infections. Regular blood tests to monitor white blood cell counts are required.
• Pregnancy Risk: Ibrance can harm an unborn baby; women of reproductive potential should use effective contraception during treatment and for at least 3 weeks after the last dose.
• Avoid Grapefruit: Do not consume grapefruit or grapefruit juice during treatment with Ibrance, as it can increase the concentration of the medication in your blood, leading to increased side effects.

Fact Table

 

Facts	Details
Generic Name	Palbociclib
Brand Name	Ibrance
Drug Class	Cyclin-dependent kinase (CDK) 4/6 inhibitor
FDA Approval	2015
Indicated for	Hormone receptor-positive, HER2-negative advanced or metastatic breast cancer
Patient Population	Postmenopausal women and men
Administration Route	Oral
Dosage Forms	Capsules (75 mg, 100 mg, 125 mg)
Typical Dosage	125 mg once daily for 21 days followed by 7 days off, in 28-day cycles
Combination Therapy	Often used in combination with an aromatase inhibitor or fulvestrant
Major Benefits	Delays disease progression, targets specific cancer cell growth pathways, administered orally
Key Side Effects	Neutropenia, infections, fatigue, nausea, hair thinning, diarrhea
Special Precautions	Regular blood tests for white cell count, liver function tests, avoid grapefruit, effective contraception required
Impact on Pregnancy	Can harm an unborn baby, contraception is required during treatment and for 3 weeks after the last dose

Common Side Effects

Like all medications, Ibrance (Palbociclib) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Infections
• Fatigue
• Nausea and Vomiting
• Hair Thinning

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Ibrance (Palbociclib)?

You can order Ibrance (Palbociclib) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.