Colchicine
Colchicine
Colchicine is a prescription medication primarily used to prevent and treat gout attacks, a form of arthritis caused by excess uric acid in the blood. It works by reducing inflammation and decreasing the buildup of uric acid crystals in the joints, which helps alleviate pain and swelling. Colchicine is also prescribed for familial Mediterranean fever (FMF) and other inflammatory conditions.
Why Choose Colchicine?
- Effectively reduces pain and inflammation associated with gout flare-ups.
- Helps prevent recurrent gout attacks when used as a maintenance therapy.
- Alleviates symptoms of familial Mediterranean fever (FMF).
- May be used to treat other inflammatory conditions as directed by your healthcare provider.
- Fast-acting relief when taken at the onset of a gout attack.
How to Use Colchicine?
- Take as directed by your healthcare provider, usually once or twice a day.
- Can be taken with or without food, but ensure to take it with a full glass of water.
- Stick to your prescribed dosage; do not take more than recommended, especially during a gout attack.
- If you miss a dose, take it as soon as you remember, but skip it if your next dose is almost due.
- Avoid consuming grapefruit or grapefruit juice, as it may interact with the medication.
- Keep hydrated by drinking plenty of water to support kidney function.
Important Safety Information about Colchicine
- Do not use Colchicine if you are allergic to it or have a history of blood disorders.
- Avoid combining Colchicine with certain medications (e.g., statins, antibiotics) unless approved by your healthcare provider.
- Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
- Stop using Colchicine and seek medical attention if you experience symptoms of severe allergic reactions, such as difficulty breathing or swelling.
Fact Table
| Facts | Details |
| Brand Name | Colcrys, Mitigare |
| Generic Name | Colchicine |
| Drug Class | Anti-inflammatory, Antigout |
| Indication | Used for the prevention and treatment of gout attacks (flares) and familial Mediterranean fever (FMF). |
| Mechanism of Action | Colchicine reduces inflammation by inhibiting the migration of white blood cells (neutrophils) to the affected area, thus reducing the swelling and pain associated with gout attacks. |
| Dosage Forms | Oral tablets, capsules |
| Strengths Available | Tablets: 0.6 mg |
| Recommended Dosage | – Gout Flare: 1.2 mg at the first sign of a flare, followed by 0.6 mg one hour later (maximum 1.8 mg in one hour). FMF: Varies based on age and medical history, typically 1.2 to 2.4 mg/day in divided doses. |
| Common Side Effects | – Diarrhea, Nausea, Abdominal pain, Vomiting |
| Drug Interactions | – CYP3A4 Inhibitors: Increased risk of toxicity when taken with drugs like clarithromycin, ketoconazole, and ritonavir. P-glycoprotein Inhibitors: Increased colchicine levels (e.g., cyclosporine, verapamil). Statins: The risk of myopathy increases with concurrent use. |
| Pregnancy & Breastfeeding | – Pregnancy Category C: Risk cannot be ruled out. Use only if needed. Breastfeeding: Colchicine is excreted in breast milk but in small amounts. Caution should be exercised if breastfeeding. |
| Warnings and Precautions | – Toxicity Risk: Colchicine has a narrow therapeutic index. Overdose can be fatal, leading to severe gastrointestinal issues, organ failure, or even death, Caution in Elderly: Increased sensitivity to drug effects. |
| Storage | Store at room temperature (20-25°C or 68-77°F). Protect from moisture and light. |
Common Side Effects
Like all medications, Colchicine can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Stomach pain or cramping
- Diarrhea
- Nausea or vomiting
- Headache
- Fatigue
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Colchicine?
You can order Colchicine using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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