Calquence (Acalabrutinib)

Calquence
Acalabrutinib

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Calquence (Acalabrutinib)

Calquence (Acalabrutinib) is a targeted therapy designed for the treatment of certain types of blood cancers, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL). As a Bruton tyrosine kinase (BTK) inhibitor, Calquence works by blocking the action of a specific enzyme necessary for the survival and proliferation of cancer cells. This medication offers a hope of improved quality of life through its targeted approach, reducing the impact on healthy cells.

Why Choose Calquence (Acalabrutinib)?

  • Targeted Action: Specifically inhibits the BTK protein, playing a crucial role in the growth and spread of malignant cells.
  • High Efficacy: Shown to improve patient outcomes significantly, including higher progression-free survival rates in clinical trials.
  • Oral Administration: Conveniently taken by mouth, allowing for treatment at home.
  • Reduced Toxicity: Generally causes fewer severe side effects compared to traditional chemotherapy.
  • Rapid Onset: Some patients may notice improvements in symptoms shortly after beginning treatment.

How to Use Calquence (Acalabrutinib)?

  • Consult Your Doctor: Ensure Calquence is prescribed by a healthcare provider familiar with your medical history.
  • Follow Prescribed Dosage: Take the medication exactly as prescribed, at the same time every day.
  • Monitor Blood Levels: Regular blood tests are necessary to monitor your response to treatment and adjust dosage if needed.
  • Manage Interactions: Avoid interactions with other medications, grapefruit, and juice.
  • Report Side Effects: Communicate any side effects to your healthcare provider immediately.
  • Continuity of Treatment: Discuss it with your doctor before taking Calquence.

Important Safety Information about Calquence

  • Blood Clot Risk: Calquence can increase the risk of blood clotting; immediate medical attention is required if symptoms of clotting like chest pain, shortness of breath, or swelling in the limbs are observed.
  • Infections: Higher susceptibility to infections; preventative measures and prompt treatment of infections are critical.
  • Liver Function: This can affect liver enzymes and function, requiring regular monitoring.
  • Pregnancy and Nursing: Not recommended for use during pregnancy or while breastfeeding due to potential harm to the baby.

Fact Table

 

Facts Details
Generic Name Acalabrutinib
Brand Name Calquence
Drug Class Bruton tyrosine kinase (BTK) inhibitor
FDA Approval Approved by the FDA for treating certain types of blood cancers such as CLL, SLL, and MCL.
Indications – Chronic Lymphocytic Leukemia (CLL) – Small Lymphocytic Lymphoma (SLL) – Mantle Cell Lymphoma (MCL)
Administration Oral capsule
Dosage Form Capsule (100 mg)
Dosage Typically 100 mg taken twice daily. Consult with a healthcare provider for specific dosing recommendations.
How It Works Inhibits the enzyme Bruton tyrosine kinase, which is essential for the growth and survival of malignant B cells.
Common Side Effects Diarrhea, headache, bruising, fatigue, muscle and joint pain, nausea.
Precautions Avoid in pregnancy and breastfeeding. Monitor for and report signs of bleeding, infection, or liver issues. Avoid concomitant use of strong CYP3A inhibitors.
Interactions Can interact with other medications affecting blood clotting, as well as some other drugs metabolized by liver enzymes.
Monitoring Required Regular blood tests to monitor liver function and blood cell counts. Regular check-ups to monitor side effects and response to treatment.
Storage Store at room temperature, away from moisture and heat.

Common Side Effects

Like all medications, Calquence (Acalabrutinib) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Diarrhea and Headache
  • Bruising
  • Fatigue
  • Muscle and Joint Pain
  • Nausea

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Calquence (Acalabrutinib)?

You can order Calquence (Acalabrutinib) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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