Cabometyx

CABOMETYX
Cabozantinib

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Frequently Asked Questions

  1. What is Cabometyx used for?

    Cabometyx is used to treat advanced kidney cancer (renal cell carcinoma), liver cancer (hepatocellular carcinoma), and certain types of thyroid cancer. It is particularly used when the cancer has progressed or in cases that are resistant to other treatments.

  2. How does Cabometyx work?

    Cabometyx is a tyrosine kinase inhibitor that blocks specific enzymes that promote cancer cell growth. It targets various pathways to inhibit tumor growth and spread.

  3. What are the common side effects of Cabometyx?

    Common side effects include diarrhea, fatigue, decreased appetite, nausea, vomiting, and weight loss. Patients might also experience high blood pressure, hand-foot syndrome, and changes in taste.

  4. How is Cabometyx taken?

    It is taken orally once a day on an empty stomach, either one hour before or two hours after eating.

  5. Can I take Cabometyx with other medications?

    Some medications and supplements can interact with Cabometyx, so always inform your doctor about everything you’re taking.

  6. Are there any dietary restrictions while taking Cabometyx?

    Patients should avoid consuming grapefruit and grapefruit juice as they can increase Cabometyx levels in the blood, leading to more severe side effects. St. John’s wort should also be avoided.

  7. How long is the treatment with Cabometyx?

    Treatment with Cabometyx continues until the disease progresses or the patient experiences unacceptable toxicity. The duration of treatment varies based on individual response and tolerance.

  8. Can Cabometyx be used in children?

    Cabometyx is approved for use in children aged 12 and older with certain thyroid cancers that have progressed after treatment. Dosage depends on body surface area.

  9. How should I store Cabometyx?

    Store it at room temperature, away from excess heat and moisture, and out of reach of children.

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References
Cabometyx (Cabozantinib) [package insert].Alameda, CA: Exelixis Inc; 2021.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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