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Zortress (Everolimus)
Zortress (Everolimus) is a prescription immunosuppressant used after kidney or liver transplant to help prevent the body from rejecting the new organ. It works by lowering the activity of the immune system so the transplanted organ can function properly. Zortress is often used in combination with other transplant medications and must be taken exactly as directed by your healthcare provider for long-term transplant success.
Why Choose Zortress (Everolimus)?
- Helps prevent organ rejection after kidney or liver transplant
- Works alongside other transplant medicines for added protection
- Designed for long-term maintenance therapy
- Available in convenient oral tablet form
- Backed by proven clinical safety and effectiveness in transplant care
How to Use Zortress (Everolimus)?
- Take exactly as prescribed by your transplant specialist
- Swallow tablets whole; do not crush or chew
- Take at the same time each day, with or without food (stay consistent)
- Regular blood tests are required to monitor drug levels
- Avoid grapefruit or grapefruit juice while taking this medication
- Inform your doctor before starting any new drug or supplement
- Store tablets at room temperature away from moisture
Important Safety Information about Zortress
- May raise cholesterol or triglyceride levels
- Can affect wound healing, notify your doctor before surgery
- May increase risk of certain cancers due to immune suppression
- Not recommended during pregnancy or while breastfeeding
- Inform your doctor if you have kidney problems, liver disease, or a history of high blood pressure
Fact Table
| Facts | Details |
| Brand Name | Zortress |
| Generic Name | Everolimus |
| Drug Class | mTOR inhibitor (mammalian target of rapamycin inhibitor) |
| Primary Use | Prevention of organ rejection after kidney or liver transplant |
| How It Works | Zortress suppresses the immune response by inhibiting mTOR, a key pathway involved in immune-cell activation and proliferation, reducing the risk of the body rejecting the transplanted organ. |
| Route of Administration | Oral tablet |
| Onset of Action | Immunosuppressive effect develops over days to weeks |
| Co-Administration | Usually prescribed along with a calcineurin inhibitor (e.g., tacrolimus) and corticosteroids in transplant patients |
| Key Contraindications | Hypersensitivity to everolimus or sirolimus (rapamycin) |
| Storage Requirements | Store at room temperature (20°C–25°C); keep in original blister pack until use |
| Common Side Effects | Mouth ulcers, high cholesterol, high blood pressure, delayed wound healing, swelling (edema), diarrhea |
| Drug Interactions | Avoid strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) & inducers (e.g., rifampin, carbamazepine) |
| Alcohol Use | Use cautiously; may worsen liver-related side effects |
| Dietary Considerations | Avoid grapefruit and grapefruit juice due to increased drug levels |
Common Side Effects
Like all medications, Zortress (Everolimus) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Headache
- Nausea or stomach discomfort
- Swelling in hands, ankles, or feet
- Cough or mild respiratory symptoms
- High blood pressure
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Zortress (Everolimus)?
You can order Zortress (Everolimus) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
