Vitrase Ovine (Hyaluronidase)

 

Vitrase Ovine (Hyaluronidase)

Vitrase Ovine (Hyaluronidase Injection, USP) is an enzyme derived from purified ovine (sheep) sources that helps increase the absorption and dispersion of injected fluids or medications. It’s commonly used as an adjuvant to enhance the effectiveness of subcutaneous or intramuscular injections and to aid in the reabsorption of fluids in tissue. Vitrase is particularly beneficial in ophthalmic procedures, improving the diffusion of local anesthetics during eye surgeries and treatments.

Why Choose Vitrase Ovine (Hyaluronidase)?

• Enhances the absorption and distribution of other injected medications.
• Assists in reducing localized tissue swelling or fluid buildup.
• Improves the effectiveness of subcutaneous or intramuscular injections.
• Facilitates faster recovery and better diffusion in ophthalmic procedures.
• Backed by clinical studies for safety and efficacy.

How to Use Vitrase Ovine (Hyaluronidase)?

• Consult your healthcare provider before administration. Vitrase should be used under medical supervision.
• Inspect the vial for clarity and particulate matter before use.
• Use a sterile syringe and needle when drawing and injecting the solution.
• Follow your provider’s instructions regarding dosage and injection site.
• Do not mix with strong oxidizing agents or certain drugs unless compatibility is confirmed.
• Dispose of used materials in an approved sharps container.

Important Safety Information about Vitrase Ovine

• For prescription use only and must be administered by or under the supervision of a healthcare professional.
• Do not use if you have known hypersensitivity to hyaluronidase or ovine proteins.
• Avoid use in infected or inflamed areas to prevent spreading infection.
• May alter the dispersion rate of concurrently administered medications. Discuss all your medications with your doctor.
• Not recommended for intravenous use or in patients with severe allergic conditions.

Fact Table

 

Facts	Details
Brand Name	Vitrase
Generic Name	Hyaluronidase (Ovine)
Drug Class	Enzyme (Hydrolytic Enzyme)
Dosage Form	Injectable solution
Active Ingredient Source	Purified from ovine (sheep) tissue
Route of Administration	Intradermal, Subcutaneous, Intramuscular, or Intraocular (depending on indication)
Primary Indications	– To increase absorption and dispersion of other injected drugs – To facilitate subcutaneous fluid administration (hypodermoclysis) – As an adjuvant in subcutaneous urography – To aid in resorption of radiopaque agents or extravasated fluids – To enhance absorption of local anesthetics and contrast agents
Mechanism of Action	Temporarily hydrolyzes hyaluronic acid in connective tissues, reducing viscosity of the extracellular matrix, thereby improving the diffusion and absorption of injected fluids or drugs.
Onset of Action	Within minutes of injection
Duration of Effect	Usually 24-48 hours
Storage Conditions	Store at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Compatibility	Compatible with most isotonic solutions; do not mix with preservatives, strong acids, alkalis, oxidants, or heavy metal salts.
Common Side Effects	– Mild local reactions such as redness, swelling, or itching at injection site – Rare allergic reactions (especially in patients with hypersensitivity to ovine proteins) – Temporary pain or burning at injection site
Contraindications	– Known hypersensitivity to hyaluronidase or ovine proteins – Infection or inflammation at intended injection site – Should not be used to enhance absorption of toxic substances or for IV administration of large fluid volumes
Precautions	– Use cautiously in patients with allergies to animal proteins. – Skin testing may be recommended before use. – Effectiveness reduced in areas with infection or inflammation due to altered tissue permeability.
Drug Interactions	May increase absorption of co-administered drugs; avoid use with epinephrine, as it may counteract hyaluronidase’s effect.
Availability	Prescription only

Common Side Effects

Like all medications, Vitrase Ovine (Hyaluronidase) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Mild pain, redness, or swelling at the injection site.
• Local irritation or itching.
• Temporary blurred vision (in ophthalmic use).
• Rare allergic reactions such as rash or hives.

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Vitrase Ovine (Hyaluronidase)?

You can order Vitrase Ovine (Hyaluronidase) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.