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Rapamune (Sirolimus)
Rapamune (Sirolimus)
Rapamune (Sirolimus) is an immunosuppressive medication prescribed to prevent organ rejection in patients who have undergone kidney transplant surgery. It works by suppressing the immune system to help the body accept the new organ and reduce the risk of complications.
Why Choose Rapamune (Sirolimus)?
- Helps prevent kidney transplant rejection.
- Proven to improve long-term transplant success rates.
- Suitable for combination therapy with other immunosuppressants.
- Easy-to-use oral formulation for patient convenience.
- Backed by extensive clinical studies and approvals.
How to Use Rapamune (Sirolimus)?
- Take as Directed: Follow your healthcare provider’s exact dosage instructions.
- Consistency is Key: Take Rapamune at the same time each day, with or without food.
- Avoid Grapefruit Products: Grapefruit and grapefruit juice can affect how Rapamune works.
- Monitor Blood Levels: Regular blood tests are necessary to adjust the dosage.
- Store Properly: Keep Rapamune in a cool, dry place away from direct sunlight.
Important Safety Information about Rapamune
- Immune System Suppression: Increases susceptibility to infections.
- Interaction Warnings: Inform your doctor about all medications or supplements you’re taking to avoid interactions.
- Pregnancy Precautions: Not recommended for use during pregnancy; consult your doctor if planning to conceive.
- Vaccination Considerations: Live vaccines should be avoided while on Rapamune.
Fact Table
| Facts | Details |
| Generic Name | Sirolimus |
| Brand Name | Rapamune |
| Drug Class | Immunosuppressant |
| Primary Indication | Prevention of organ rejection in kidney transplant patients |
| Mechanism of Action | Inhibits the mammalian target of rapamycin (mTOR), reducing T-cell activation and immune response |
| Dosage Forms | Tablets (1 mg, 2 mg) and Oral Solution (1 mg/mL) |
| Administration Route | Oral |
| Recommended Dosage | – Loading dose: 6 mg once after transplant – Maintenance dose: 2 mg daily (adjusted per blood levels) |
| Bioavailability | ~14% (oral solution); slightly lower for tablets |
| Food Interaction | High-fat meals reduce absorption; avoid grapefruit and grapefruit juice |
| Storage Instructions | – Tablets: Store at 20°C to 25°C (68°F to 77°F) – Oral Solution: Refrigerate at 2°C to 8°C (36°F to 46°F) |
| Contraindications | – Hypersensitivity to Sirolimus – Live vaccinations during treatment |
| Common Side Effects | Headache, diarrhea, nausea, abdominal pain, joint pain, rash, acne |
| Drug Interactions | – Avoid use with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) – Monitor closely with other immunosuppressants |
| FDA Approval Date | September 1999 |
Common Side Effects
Like all medications, Rapamune (Sirolimus) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Headache
- Diarrhea
- Joint pain
- Abdominal discomfort
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Rapamune (Sirolimus)?
You can order Rapamune (Sirolimus) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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