Prograf (Tacrolimus)

 

Prograf (Tacrolimus)

Prograf (Tacrolimus) is an immunosuppressant medication primarily used to prevent the body from rejecting a transplanted organ such as a liver, kidney, or heart. It works by lowering the activity of your immune system, making it less likely to attack the transplanted organ. Prograf is typically prescribed as part of a combination therapy alongside other immunosuppressants to ensure optimal results.

Why Choose Prograf (Tacrolimus)?

• Reduces the risk of organ rejection in post-transplant patients.
• Offers reliable, long-term immunosuppression when taken as directed.
• Available in various strengths to meet individualized dosing needs.
• Proven track record in successful organ transplantation across multiple organ types.

How to Use Prograf (Tacrolimus)?

• Take exactly as prescribed: Follow your doctor’s instructions carefully regarding the dosage and frequency.
• Consistent timing: Take Prograf at the same time each day, with or without food, to maintain steady drug levels in your body.
• Avoid certain foods: Grapefruit and grapefruit juice can interfere with Tacrolimus levels, so avoid them while on this medication.
• Stay hydrated: Drink plenty of water unless advised otherwise by your healthcare provider.
• Frequent monitoring: Regular blood tests may be required to monitor your Tacrolimus levels and ensure proper kidney and liver function.
• Avoid missed doses: If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose—never double up.

Important Safety Information about Prograf

• Infection risk: Since Prograf suppresses your immune system, you may be at higher risk of infections. Report any signs of infection, such as fever or persistent cough, to your doctor immediately.
• Organ function monitoring: Regular checkups are crucial to monitor kidney and liver health while on Prograf.
• Interaction caution: Avoid using other medications, supplements, or herbal products without consulting your healthcare provider, as they may interfere with Prograf.
• Pregnancy & breastfeeding: Use only if needed and prescribed by your doctor, as Tacrolimus can affect an unborn baby or pass into breast milk.

Fact Table

 

Facts	Details
Generic Name	Tacrolimus
Brand Name	Prograf
Drug Class	Calcineurin Inhibitor (Immunosuppressant)
Purpose	To prevent organ rejection in patients who have undergone liver, kidney, or heart transplants
Mechanism of Action	Inhibits calcineurin, reducing T-cell activation and immune response, preventing rejection
Dosage Forms	Oral Capsules, Oral Granules for suspension, Intravenous Injection
Typical Dosage	Individualized based on organ type, body weight, and blood levels
Route of Administration	Oral or Intravenous
Frequency of Administration	Twice daily (every 12 hours)
Metabolism	Primarily in the liver by CYP3A enzymes
Primary Indications	– Prevention of liver, kidney, or heart transplant rejection
Off-Label Uses	– Autoimmune diseases (e.g., lupus nephritis, atopic dermatitis)
Key Benefits	– Effective immunosuppression to prevent organ rejection – Versatile dosing options
Important Warnings	– Increased risk of infections and certain cancers – Monitor for nephrotoxicity and neurotoxicity
Drug Interactions	– CYP3A inhibitors (e.g., ketoconazole, erythromycin) may increase tacrolimus levels – CYP3A inducers (e.g., rifampin, phenytoin) may decrease tacrolimus levels
Common Side Effects	– Tremors – Headache – Nausea – Hypertension – Kidney dysfunction
Storage Conditions	Store at room temperature (20°C to 25°C)

Common Side Effects

Like all medications, Prograf (Tacrolimus) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Tremors
• Headache
• High blood pressure
• Nausea and vomiting
• Diarrhea
• Increased blood sugar levels
• Trouble sleeping

If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Prograf (Tacrolimus)?

You can order Prograf (Tacrolimus) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.