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Nuedexta (Dextromethorphan/ Quinidine)
Nuedexta (Dextromethorphan/ Quinidine)
Nuedexta (Dextromethorphan/Quinidine) is a prescription treatment designed to manage pseudobulbar affect (PBA), a condition that causes sudden, uncontrollable episodes of crying or laughing. It works by balancing certain neurotransmitters in the brain to help reduce the frequency and severity of emotional outbursts. Nuedexta combines dextromethorphan, which acts on the central nervous system, with quinidine, which helps maintain the right level of dextromethorphan in the body for optimal effectiveness.
Why Choose Nuedexta (Dextromethorphan/ Quinidine)?
- Helps control involuntary emotional episodes associated with PBA.
- Proven to improve emotional stability and quality of life.
- Begins showing results within a few weeks of consistent use.
- May also support better social interaction and daily functioning.
How to Use Nuedexta (Dextromethorphan/ Quinidine)?
- Take Nuedexta exactly as prescribed by your healthcare provider.
- Usually taken once every 12 hours (two doses per day).
- Swallow capsules whole, without crushing or chewing.
- If a dose is missed, take it as soon as you remember; do not double up on doses.
- Store at room temperature, away from heat and moisture.
- Regular follow-ups with your doctor are recommended to monitor progress and side effects.
Important Safety Information about Nuedexta
- Do not use Nuedexta if you have a history of heart rhythm disorders, heart failure, or are taking MAO inhibitors.
- Inform your doctor if you have liver problems, electrolyte imbalances, or are on medications that affect heart rhythm (QT prolongation).
- Avoid alcohol and drugs that cause drowsiness while taking Nuedexta.
- Discuss all current medications and supplements with your provider to avoid potential drug interactions.
Fact Table
| Facts | Details |
| Brand Name | Nuedexta |
| Generic Name | Dextromethorphan Hydrobromide and Quinidine Sulfate |
| Active Ingredients | Dextromethorphan HBr 20 mg and Quinidine Sulfate 10 mg per capsule |
| Dosage Form | Oral capsule |
| Route of Administration | By mouth (oral use only) |
| Therapeutic Class | Central Nervous System (CNS) agent / Antitussive and Antiarrhythmic combination |
| Primary Indication | Treatment of Pseudobulbar Affect (PBA), a neurological condition causing sudden, uncontrollable episodes of laughing or crying that are disproportionate or inappropriate to the situation |
| Mechanism of Action | – Dextromethorphan acts on the sigma-1 receptor and NMDA receptors in the brain to modulate neurotransmission. – Quinidine inhibits the metabolism of dextromethorphan by blocking the CYP2D6 enzyme, increasing its bioavailability and duration of effect. |
| Onset of Action | Noticeable improvement in symptoms typically observed within 1–2 weeks of consistent use |
| Contraindications | – Prolonged QT interval or history of torsades de pointes – Complete atrioventricular (AV) block without a pacemaker – Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuation – Hypersensitivity to quinidine, quinine, or mefloquine |
| Warnings and Precautions | – May cause QT prolongation and risk of serious arrhythmia. – Avoid use with other QT-prolonging drugs.- Monitor for dizziness, fainting, or irregular heartbeat. – May cause serotonin syndrome when combined with certain antidepressants (SSRIs, SNRIs, or MAOIs). |
| Common Side Effects | – Diarrhea – Dizziness – Cough – Vomiting – Fatigue – Swelling of feet or ankles |
| Drug Interactions | – Do not combine with: MAO inhibitors, tricyclic antidepressants, SSRIs, SNRIs, antipsychotics, and strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, bupropion). – Avoid use with drugs that prolong QT interval. |
| Storage Conditions | Store at 20°C to 25°C (68°F to 77°F); protect from moisture and light. |
| Overdose Management | In case of overdose, seek immediate medical attention; symptoms may include cardiac arrhythmias, dizziness, and CNS depression. |
| Prescription Status | Prescription-only |
Common Side Effects
Like all medications, Nuedexta (Dextromethorphan/ Quinidine) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Dizziness or lightheadedness
- Diarrhea or stomach upset
- Swelling in hands or feet
- Cough or flu-like symptoms
- Fatigue or weakness
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Nuedexta (Dextromethorphan/ Quinidine)?
You can order Nuedexta (Dextromethorphan/ Quinidine) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
