Januvia (Sitagliptin)

Januvia
Sitagliptin Phosphate

Source:
Source:
Source:
Januvia
Sitagliptin Phosphate

Source:
Source:
Source:



JANUVIA (SITAGLIPTIN PHOSPHATE)

  • Overview

    Januvia (Sitagliptin Phosphate) is an oral prescription drug used to treat high blood sugar levels caused by type 2 diabetes. Januvia is the brand name. Moreover, it is not available as a generic drug. FDA however, approved it in October 2006. The prescription above all comes typically along with diet and exercise.

  • How It Works

    Insulin is a chemical that helps to remove sugar from the blood and transfer it to the cells to break it down and use it for energy. Moreover, Januvia (Sitagliptin Hydrochloride) belongs to the certain category drugs. They are known as DPP-4. In addition, Incretin is a hormone responsible for the insulin production and realization. Januvia (Sitagliptin Phosphate) drug protects the incretin hormone from breaking down too quickly, which helps to increase the production and release of insulin. In other words, it also reduces glucose secretion by the liver. Therefore, this is how Januvia works to lower blood sugar levels in patients with type 2 diabetes.

  • Dosage

    • Above all, it is not recommended for children under 18 years.
    Adult Dosage:
    • An initial dose of 100 mg once daily can be taken with or without meals, for instance.
    • Changes in dosage, however, depends on renal function and blood sugar levels.
    Senior Dosage: The dosage depends on the kidney function for older people.
    • Mild Kidney Problems: 100 mg once daily.
    • Moderate Kidney Problems: 50 mg once daily.
    • Severe Kidney Problems: 25 mg once daily.

  • Common Side Effects

    Serious Side Effects:

    • Pancreatitis: Symptoms are,
      1. Severe pain in stomach travelling from your stomach to back.
      2. Vomiting
    • Kidney problems: Symptoms are,
      1. Swelling of feet, ankles and legs.
      2. Chest Pain
      3. Nausea
      4. Less Urine
      5. Drowsiness
    • Bullous Pemphigoid: Symptoms are,
      1. Itchy Skin
      2. Skin Erosion
      3. Fluid-filled blisters
      4. Hypoglycemia
      5. Allergic reactions
    Common Side Effects:
    • Stomach Pain
    • Diarrhoean
    • Headache
    • Stuffy, Runny Nose or Sore Throat
    These are some side effects of this drug. If you have any of these symptoms, call for immediate medical help.

  • How to Take This Medication

    • Take this medicine as and when prescribed by your doctor.
    • Read the instructions and information carefully before you start this medication.
    • You can consume it with or without a meal.
    • Fix a time to take medicine, so you don’t miss a dose.
    • Avoid taking a double dose if at all, you miss a dosage. Wait for the next dosage.
    • If you overdose, contact your doctor immediately.
    • Don’t change your dose without consulting the doctor.
    • Use it with improved diet and exercise.

  • Warnings and Precautions

    • Important Warnings:
      1. Pancreatitis: Januvia (Sitagliptin Phosphate) may increase your risk of Pancreatitis.
      2. Joint Pain: This drug may cause severe joint pain.
    • Other Warnings and Precautions:
      • Don’t take this drug if you have,
        1. Allergic Reaction
        2. Diabetes Ketoacidosis
        3. Kidney Problems
        4. Pancreatitis
    • Inform your doctor if you have/are,
      1. Kidney Problems
      2. Pregnant or planning to get pregnant
      3. Breastfeeding
      4. Going to undergo a surgery
      5. Taking any other diabetic medication.
    • Senior people should first monitor their kidney function.
    • It is not recommended for children below 18 years.
    • Avoid Smoking and Alcohol.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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