Evotaz (Atazanavir/ Cobicistat)
Evotaz (Atazanavir/ Cobicistat)
Evotaz is a prescription combination medicine containing Atazanavir (an HIV-1 protease inhibitor) and Cobicistat (a pharmacokinetic enhancer). It is used with other antiretroviral agents to help manage HIV-1 infection in adults. Evotaz works by lowering the amount of HIV in the blood, helping the immune system function better, and reducing the risk of HIV-related complications. It is not a cure for HIV or AIDS, but it plays a key role in effective long-term management.Why Choose Evotaz (Atazanavir/ Cobicistat)?
- Combines two active ingredients in a single tablet for simplified dosing.
- Helps suppress HIV-1 viral load when taken with other antiretroviral therapies.
- Improves immune system health by reducing virus levels.
- Convenient once-daily tablet to support treatment adherence.
- Proven safety and efficacy when used as part of a complete treatment plan.
How to Use Evotaz (Atazanavir/ Cobicistat)?
- Take Evotaz once daily with food, exactly as prescribed by your healthcare provider.
- Always use it in combination with other HIV medicines; never use it alone.
- Do not skip doses; consistent use is essential to prevent drug resistance.
- If you miss a dose, take it as soon as you remember. If it’s near the time of your next dose, skip the missed dose; do not double up.
- Keep regular medical and lab appointments to monitor viral load, liver function, and overall health.
Important Safety Information about Evotaz
- Do not use if you are allergic to Atazanavir, Cobicistat, or any component of the tablet.
- Inform your doctor if you have liver problems, kidney disease, or heart rhythm issues before starting.
- May interact with other medicines, including acid-reducing agents, blood thinners, anticonvulsants, and certain antibiotics. Disclose all medications to your provider.
- Not recommended for use with strong CYP3A inducers, as they may reduce the effectiveness of Evotaz.
- Pregnant or breastfeeding individuals should discuss risks and benefits with their healthcare provider.
Fact Table
| Facts | Details |
| Brand Name | Evotaz |
| Generic Name | Atazanavir / Cobicistat |
| Drug Class | Antiretroviral (Protease Inhibitor + Pharmacokinetic Enhancer) |
| Indication | Used in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults |
| Formulation | Oral tablet |
| Route of Administration | Oral (by mouth) |
| Dosing Frequency | Once daily |
| Administration | Must be taken with food for proper absorption |
| Mechanism of Action | - Atazanavir: Inhibits HIV-1 protease enzyme, preventing viral replication. - Cobicistat: Acts as a booster by inhibiting CYP3A enzymes, increasing Atazanavir levels. |
| Contraindications | - Known hypersensitivity to Atazanavir, Cobicistat, or formulation components - Concurrent use with strong CYP3A inducers (e.g., rifampin, carbamazepine, St. John’s Wort) - Use with drugs highly dependent on CYP3A for clearance and with narrow therapeutic index (e.g., certain antiarrhythmics, ergot derivatives, PDE-5 inhibitors for pulmonary hypertension, etc.) |
| Warnings & Precautions | - Liver toxicity: Monitor in patients with hepatic impairment - Renal impairment: Monitor closely if using with tenofovir disoproxil fumarate - Cardiac conduction abnormalities: May cause PR interval prolongation - Hyperbilirubinemia: Reversible increases in indirect bilirubin (jaundice, scleral icterus) - Drug interactions: Significant potential with CYP3A substrates, inducers, and inhibitors |
| Drug Interactions | - Avoid strong CYP3A inducers (e.g., rifampin, phenytoin, phenobarbital) - May interact with proton pump inhibitors, H2 blockers, antacids (affect absorption of Atazanavir) - Caution with anticoagulants, anticonvulsants, certain antibiotics/antifungals, and other antiretrovirals |
| Common Side Effects | - Nausea, vomiting, diarrhea - Headache - Rash - Jaundice (yellowing of skin/eyes) - Indigestion, abdominal pain - Fatigue |
| Storage | Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F–86°F). Keep in original container. |
| Availability | Prescription-only medicine |
Common Side Effects
Like all medications, Evotaz (Atazanavir/ Cobicistat) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.- Nausea or stomach pain
- Headache
- Skin rash or yellowing of the skin/eyes (jaundice)
- Indigestion or bloating
- Tiredness or weakness
How Can You Buy Evotaz (Atazanavir/ Cobicistat)?
You can order Evotaz (Atazanavir/ Cobicistat) using these methods on our website:- Order Online
- Order by Phone
- Order by Fax
- Order your refills
