Evotaz (Atazanavir/ Cobicistat)
Evotaz (Atazanavir/ Cobicistat)
Evotaz is a prescription combination medicine containing Atazanavir (an HIV-1 protease inhibitor) and Cobicistat (a pharmacokinetic enhancer). It is used with other antiretroviral agents to help manage HIV-1 infection in adults. Evotaz works by lowering the amount of HIV in the blood, helping the immune system function better, and reducing the risk of HIV-related complications. It is not a cure for HIV or AIDS, but it plays a key role in effective long-term management.
Why Choose Evotaz (Atazanavir/ Cobicistat)?
- Combines two active ingredients in a single tablet for simplified dosing.
- Helps suppress HIV-1 viral load when taken with other antiretroviral therapies.
- Improves immune system health by reducing virus levels.
- Convenient once-daily tablet to support treatment adherence.
- Proven safety and efficacy when used as part of a complete treatment plan.
How to Use Evotaz (Atazanavir/ Cobicistat)?
- Take Evotaz once daily with food, exactly as prescribed by your healthcare provider.
- Always use it in combination with other HIV medicines; never use it alone.
- Do not skip doses; consistent use is essential to prevent drug resistance.
- If you miss a dose, take it as soon as you remember. If it’s near the time of your next dose, skip the missed dose; do not double up.
- Keep regular medical and lab appointments to monitor viral load, liver function, and overall health.
Important Safety Information about Evotaz
- Do not use if you are allergic to Atazanavir, Cobicistat, or any component of the tablet.
- Inform your doctor if you have liver problems, kidney disease, or heart rhythm issues before starting.
- May interact with other medicines, including acid-reducing agents, blood thinners, anticonvulsants, and certain antibiotics. Disclose all medications to your provider.
- Not recommended for use with strong CYP3A inducers, as they may reduce the effectiveness of Evotaz.
- Pregnant or breastfeeding individuals should discuss risks and benefits with their healthcare provider.
Fact Table
| Facts | Details |
| Brand Name | Evotaz |
| Generic Name | Atazanavir / Cobicistat |
| Drug Class | Antiretroviral (Protease Inhibitor + Pharmacokinetic Enhancer) |
| Indication | Used in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults |
| Formulation | Oral tablet |
| Route of Administration | Oral (by mouth) |
| Dosing Frequency | Once daily |
| Administration | Must be taken with food for proper absorption |
| Mechanism of Action | – Atazanavir: Inhibits HIV-1 protease enzyme, preventing viral replication. – Cobicistat: Acts as a booster by inhibiting CYP3A enzymes, increasing Atazanavir levels. |
| Contraindications | – Known hypersensitivity to Atazanavir, Cobicistat, or formulation components – Concurrent use with strong CYP3A inducers (e.g., rifampin, carbamazepine, St. John’s Wort) – Use with drugs highly dependent on CYP3A for clearance and with narrow therapeutic index (e.g., certain antiarrhythmics, ergot derivatives, PDE-5 inhibitors for pulmonary hypertension, etc.) |
| Warnings & Precautions | – Liver toxicity: Monitor in patients with hepatic impairment – Renal impairment: Monitor closely if using with tenofovir disoproxil fumarate – Cardiac conduction abnormalities: May cause PR interval prolongation – Hyperbilirubinemia: Reversible increases in indirect bilirubin (jaundice, scleral icterus) – Drug interactions: Significant potential with CYP3A substrates, inducers, and inhibitors |
| Drug Interactions | – Avoid strong CYP3A inducers (e.g., rifampin, phenytoin, phenobarbital) – May interact with proton pump inhibitors, H2 blockers, antacids (affect absorption of Atazanavir) – Caution with anticoagulants, anticonvulsants, certain antibiotics/antifungals, and other antiretrovirals |
| Common Side Effects | – Nausea, vomiting, diarrhea – Headache – Rash – Jaundice (yellowing of skin/eyes) – Indigestion, abdominal pain – Fatigue |
| Storage | Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F–86°F). Keep in original container. |
| Availability | Prescription-only medicine |
Common Side Effects
Like all medications, Evotaz (Atazanavir/ Cobicistat) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Nausea or stomach pain
- Headache
- Skin rash or yellowing of the skin/eyes (jaundice)
- Indigestion or bloating
- Tiredness or weakness
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Evotaz (Atazanavir/ Cobicistat)?
You can order Evotaz (Atazanavir/ Cobicistat) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
