Elestrin (Estradiol)
Elestrin (Estradiol)
Elestrin (Estradiol) is a prescription topical gel used to treat moderate to severe hot flashes caused by menopause. By delivering estrogen directly through the skin, it helps restore hormonal balance and relieve discomfort associated with menopause. Its easy-to-apply formula offers a convenient alternative to oral estrogen therapies.
Why Choose Elestrin (Estradiol)?
- Relieves moderate to severe hot flashes during menopause
- Helps restore estrogen levels in the body
- Easy-to-use gel applied directly to the skin
- Offers a non-oral alternative for hormone replacement therapy
- Provides consistent absorption for effective symptom relief
How to Use Elestrin (Estradiol)?
- Apply only as directed by your healthcare provider
- Use the recommended dose once daily, usually to the upper arm area
- Allow the gel to dry completely before covering with clothing
- Wash your hands thoroughly after application
- Avoid contact with the eyes, mouth, and broken skin
- Keep away from children and pets
Important Safety Information about Elestrin
- Not suitable for women with a history of breast cancer, uterine cancer, stroke, heart attack, or blood clots
- Inform your doctor if you have liver disease, high blood pressure, diabetes, or a history of migraine headaches
- Long-term use of estrogen may increase the risk of certain cancers and cardiovascular events
- Regular checkups, including breast and pelvic exams, are recommended while using this medication
- Do not use during pregnancy or breastfeeding
Fact Table
| Facts | Details |
| Brand Name | Elestrin |
| Generic Name | Estradiol |
| Dosage Form | Topical Gel |
| Strength(s) Available | 0.06% (0.87 g per pump delivers 0.52 mg estradiol) |
| Indication | Treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause |
| Route of Administration | Transdermal (applied to skin, usually upper arm/shoulder) |
| Mechanism of Action | Estradiol, a form of estrogen, replaces declining estrogen levels during menopause. It binds to estrogen receptors, regulating gene expression and reducing symptoms such as hot flashes. |
| Onset of Action | Symptom relief may begin within 1–3 weeks; full effect typically observed after several weeks of consistent use |
| Usual Dosage | One pump (0.87 g gel = 0.52 mg estradiol) applied once daily to clean, dry skin of upper arm/shoulder |
| Administration Notes | Apply to the same general area each day; allow to dry before dressing; wash hands after application; avoid contact with eyes, mouth, or broken skin |
| Contraindications | – Known or suspected breast cancer – Estrogen-dependent neoplasia – Active or history of blood clots (DVT/PE) – History of stroke or myocardial infarction – Liver dysfunction or disease – Known or suspected pregnancy |
| Warnings & Precautions | – Increased risk of endometrial hyperplasia and cancer (if used without progestin in women with intact uterus) – May increase risk of breast cancer, stroke, DVT/PE, and cardiovascular events – Monitor blood pressure, triglycerides, and thyroid function in long-term use |
| Drug Interactions | – CYP3A4 inducers (rifampin, phenytoin, carbamazepine) may reduce efficacy – CYP3A4 inhibitors (ketoconazole, erythromycin, grapefruit juice) may increase estradiol exposure – May affect thyroid hormone replacement therapy (altered binding proteins) |
| Storage | Store at 20°C to 25°C (68°F to 77°F); do not freeze; keep pump tightly closed |
| Common Side Effects | – Skin irritation at application site – Breast tenderness – Headache – Nausea – Bloating – Mood changes |
Common Side Effects
Like all medications, Elestrin (Estradiol) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Skin redness or irritation at the application site
- Breast tenderness or pain
- Headache or mild nausea
- Mood changes
- Weight changes or bloating
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Elestrin (Estradiol)?
You can order Elestrin (Estradiol) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
