Cotellic (Cobimetinib Fumarate)

 

Cotellic (Cobimetinib Fumarate)

Cotellic (Cobimetinib Fumarate) is a prescription medicine used in combination with vemurafenib to treat adults with melanoma (a type of skin cancer) that has spread or cannot be removed by surgery and has a certain type of abnormal “BRAF” gene. By targeting specific proteins involved in cancer growth, Cotellic helps slow down or stop the spread of cancer cells.

Why Choose Cotellic (Cobimetinib Fumarate)?

• Works in combination therapy to improve treatment outcomes in melanoma.
• Targets abnormal signaling pathways that drive tumor growth.
• Oral medication taken in tablet form for ease of use.
• Clinically shown to help extend progression-free survival.
• Helps reduce the risk of cancer spreading further in patients with BRAF V600 mutation-positive melanoma.

How to Use Cotellic (Cobimetinib Fumarate)?

• Take Cotellic exactly as prescribed by your healthcare provider.
• Recommended dosage is typically once daily, with or without food.
• Do not take more than the prescribed dose or make up for missed doses without medical advice.
• Inform your doctor about all other medicines you are taking to avoid drug interactions.
• Regular monitoring with blood tests and eye exams may be required during treatment.
• Always follow your oncologist’s instructions when combining Cotellic with vemurafenib.

Important Safety Information about Cotellic

• Not recommended for patients without the BRAF V600 mutation.
• May cause serious side effects, including bleeding, heart problems, skin sensitivity, and eye issues.
• Avoid exposure to direct sunlight; use protective clothing and sunscreen.
• Women of childbearing potential should use effective contraception during treatment and for at least 2 weeks after the last dose.

Fact Table

 

Facts	Details
Brand Name	Cotellic
Generic Name	Cobimetinib Fumarate
Drug Class	Kinase inhibitor (specifically MEK inhibitor)
Indication	Used in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.
Mechanism of Action	Selectively inhibits MEK1 and MEK2 (mitogen-activated extracellular signal regulated kinases). This blocks the MAPK signaling pathway, reducing cancer cell proliferation.
Dosage Form	Oral tablets
Recommended Dose	60 mg (three 20 mg tablets) orally once daily for the first 21 days of each 28-day cycle (followed by 7 days off treatment). Always used in combination with vemurafenib.
Administration	Taken with or without food. Swallow tablets whole with water.
Contraindications	Known hypersensitivity to cobimetinib or any excipients.
Important Safety Information	Risk of hemorrhage, cardiomyopathy, ocular toxicity (serous retinopathy, retinal vein occlusion), hepatotoxicity, rhabdomyolysis, and severe skin reactions. Requires close monitoring.
Monitoring Parameters	Liver function tests, creatine phosphokinase (CPK) levels, cardiac function (LVEF), dermatologic evaluations, and ophthalmologic exams as needed.
Common Side Effects	Diarrhea, nausea, vomiting, fever, rash, photosensitivity, fatigue, increased liver enzymes, elevated CPK, muscle pain.
Drug Interactions	Strong or moderate CYP3A inhibitors (e.g., ketoconazole, clarithromycin) may increase cobimetinib levels. CYP3A inducers (e.g., rifampin, carbamazepine, St. John’s wort) may decrease efficacy. Avoid grapefruit products.
Pregnancy & Lactation	May cause fetal harm. Not recommended during pregnancy or breastfeeding. Effective contraception required during treatment and for at least 2 weeks after the final dose.
Storage	Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15–30°C (59–86°F). Protect from moisture.

Common Side Effects

Like all medications, Cotellic (Cobimetinib Fumarate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Diarrhea
• Rash or skin sensitivity to sunlight
• Nausea and vomiting
• Fever
• Abdominal pain

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Cotellic (Cobimetinib Fumarate)?

You can order Cotellic (Cobimetinib Fumarate) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.