Aloxi (Palonosetron Hydrochloride)
Aloxi (Palonosetron Hydrochloride)
Aloxi (Palonosetron Hydrochloride) is a prescription medicine used to help prevent nausea and vomiting associated with certain chemotherapy treatments. It belongs to a class of drugs known as serotonin 5-HT3 receptor antagonists, which work by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting during cancer treatment. Aloxi provides long-lasting relief with a single dose, making it a convenient option for patients undergoing chemotherapy.
Why Choose Aloxi (Palonosetron Hydrochloride)?
- Helps prevent both acute (immediate) and delayed (later onset) nausea and vomiting caused by chemotherapy.
- Provides long-lasting protection with a single intravenous dose.
- Reduces the need for multiple anti-nausea medications.
- Improves overall comfort and quality of life during chemotherapy cycles.
How to Use Aloxi (Palonosetron Hydrochloride)?
- Aloxi is given by a healthcare professional as an intravenous injection.
- It is usually administered about 30 minutes before chemotherapy starts.
- Follow all instructions provided by your doctor or oncology team.
- Do not attempt to self-administer unless specifically trained and instructed by a healthcare provider.
Important Safety Information about Aloxi
- Not recommended for patients with known hypersensitivity to palonosetron or any ingredients in Aloxi.
- Inform your doctor about any heart conditions, irregular heartbeat, or electrolyte imbalances before receiving Aloxi.
- Use with caution if taking other medicines that may affect heart rhythm.
- Aloxi is not approved for the prevention of nausea/vomiting related to radiation therapy or surgery in pediatric patients.
- Always disclose your full list of medications and supplements to your healthcare provider to avoid interactions.
Fact Table
| Facts | Details |
| Generic Name | Palonosetron Hydrochloride |
| Brand Name | Aloxi |
| Drug Class | 5-HT3 (serotonin) receptor antagonist |
| Indication / Uses | – Prevention of acute nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC) – Prevention of delayed nausea and vomiting associated with MEC – Prevention of postoperative nausea and vomiting (PONV) (single-dose prophylaxis) |
| Dosage Forms | – Intravenous (IV) injection – Oral capsule (varies by market availability) |
| Strengths | – IV injection: 0.25 mg/5 mL (single-dose vial) – Oral capsule: 0.5 mg (where available) |
| Recommended Dosage | Chemotherapy-induced nausea/vomiting (CINV): 0.25 mg IV administered as a single dose ~30 minutes before chemotherapy – Postoperative nausea/vomiting (PONV): 0.075 mg IV administered once immediately before induction of anesthesia |
| Mechanism of Action | Selectively blocks serotonin (5-HT3) receptors both peripherally (in the gastrointestinal tract) and centrally (in the chemoreceptor trigger zone of the brain), reducing the stimulation that causes nausea and vomiting. |
| Onset of Action | Within 30 minutes (IV) |
| Duration of Action | Up to 72 hours, making it longer-lasting than many other 5-HT3 antagonists |
| Common Side Effects | – Headache – Constipation – Fatigue – Dizziness |
| Contraindications | – Known hypersensitivity to palonosetron or any component of the formulation |
| Drug Interactions | – Use caution with other drugs that prolong the QT interval – Substrate of CYP2D6; potential interaction with strong inhibitors/inducers |
| Storage | Store vials at 20°C to 25°C (68°F to 77°F); protect from light and freezing |
Common Side Effects
Like all medications, Aloxi (Palonosetron Hydrochloride) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Headache
- Constipation
- Fatigue or tiredness
- Dizziness
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Aloxi (Palonosetron Hydrochloride)?
You can order Aloxi (Palonosetron Hydrochloride) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
