Aggrenox (Dipyridamole/Acetylsalicylic Acid)

Generic Equivalents   What's the difference?
Dipyridamole/ASA
Dipyridamole, Acetylsalicylic Acid

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Aggrenox (Dipyridamole / Acetylsalicylic Acid)

Aggrenox combines the potency of Dipyridamole and Acetylsalicylic Acid (Aspirin) in a novel formulation intended to prevent stroke in those who have had a transient ischemia (mini-stroke) or a full ischemic stroke caused by thrombosis. Aggrenox reduces the likelihood of blood clots while boosting blood flow to the brain, providing a proactive approach to stroke prevention.

Why Choose Aggrenox (Dipyridamole / Acetylsalicylic Acid)?

  • Dual-Action Formula: Aggrenox’s unique combination of Dipyridamole and Aspirin has a synergistic effect, giving greater protection against the formation of blood clots than either drug alone.

  • Clinically Proven: Based on comprehensive clinical trials, Aggrenox has been shown to greatly lower the incidence of recurrent stroke.

  • Convenient dosage: Aggrenox’s twice-daily dosage regimen is designed for ease of use and increased compliance.

How to Use Aggrenox (Dipyridamole / Acetylsalicylic Acid)?

  • Take Aggrenox exactly as directed by your healthcare provider.

  • Typically given twice per day, in the morning and evening, with or without meals.

  • Swallow the capsule whole, without crushing or chewing.

  • Consistent use at the same times throughout the day enhances effectiveness.

Important Safety Information about Aggrenox

  • Before taking Aggrenox, let your doctor know if you have any allergies, or medical conditions, or are taking any other drugs, particularly blood thinners or NSAIDS.
  • Individuals with a history of severe liver or renal illness, certain forms of cardiac disease, or recent bleeding disorders should avoid taking this medication.

  • Aggrenox’s blood-thinning effects may raise the risk of bleeding. Exercise caution when participating in activities that could cause damage.

  • Pregnant or nursing moms should consult their doctor before taking Aggrenox.

Fact Table for Aggrenox

Generic Name Dipyridamole / Acetylsalicylic Acid

Brand Name

Aggrenox
Classification Antiplatelet

Approved Uses

Primarily used to reduce the risk of stroke in patients who have had transient ischemia of the brain or a completed ischemic stroke due to thrombosis.

Mechanism of Action Dipyridamole works by inhibiting the uptake of adenosine into erythrocytes and endothelial cells, leading to increased blood flow to the heart. Aspirin inhibits platelet aggregation by irreversibly inhibiting the COX-1 enzyme, thereby reducing the formation of thromboxane A2, a platelet activator.

Dosage Forms

Oral capsule
Common Dosages
25 mg/200 mg (Aspirin/Dipyridamole) twice daily
Side Effects

Headache, dizziness, abdominal pain, nausea, diarrhea, and bleeding are among the most common.

Key Warnings & Precautions Increased risk of bleeding, especially in patients with peptic ulcer disease or those receiving anticoagulants. Patients with hypersensitivity to NSAIDs or salicylates should avoid use. Not recommended for patients with severe liver or kidney impairment.

Pregnancy Category Category D (Evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, e.g., if the drug is needed in a life-threatening situation)

Interactions Anticoagulants, NSAIDs, selective serotonin reuptake inhibitors (SSRIs), and other drugs that increase bleeding risk.
Alcohol Interaction Alcohol may increase the risk of stomach bleeding.

Storage Instructions Store at room temperature away from moisture and heat.

Pharmacokinetics

Dipyridamole: Peak plasma concentrations reached in about 2.5 hours.Aspirin:Rapidly absorbed, with a peak concentration in 15-20 minutes. Both components undergo hepatic metabolism.

Common Side Effects of Aggrenox

Like all medications, Aggrenox (Dipyridamole / Acetylsalicylic Acid) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Headache
  • Dizziness
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Bleeding

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Aggrenox (Dipyridamole / Acetylsalicylic Acid)?

You can order Aggrenox (Dipyridamole / Acetylsalicylic Acid) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. What is Aggrenox used for?

    Aggrenox is a combination medication containing aspirin and dipyridamole, used to reduce the risk of stroke in people who have had transient ischemic attacks (mini-strokes) or a previous stroke caused by blood clots.

  2. How does Aggrenox work?

    Aggrenox combines two active ingredients: aspirin, which prevents blood clots by stopping platelets from clumping together, and dipyridamole, which also helps prevent clots by improving blood flow to the brain.

  3. How should I take Aggrenox?

    Aggrenox is typically taken twice daily, in the morning and evening. Swallow the capsules whole without chewing, and follow your doctor’s instructions closely for the best results.

  4. What are the common side effects of Aggrenox?

    Common side effects include headaches, nausea, upset stomach, diarrhea, and heartburn. These symptoms often lessen with continued use, but if they persist or worsen, contact your doctor.

  5. Can I take Aggrenox if I’m pregnant or breastfeeding?

    Aggrenox is generally not recommended during pregnancy, especially in the third trimester, due to potential risks to the baby. Breastfeeding while taking Aggrenox is also not advised.

  6. Can I take Aggrenox with other medications?

    Aggrenox can interact with several other medications, including blood thinners, NSAIDs, and certain blood pressure drugs. Always inform your doctor about all the medications and supplements you are taking to avoid dangerous interactions.

  7. Is it normal to have headaches when starting Aggrenox?

    Yes, headaches are a common side effect when first starting Aggrenox, but they often improve over time. If headaches are severe or persistent, consult your doctor, who may adjust your treatment plan.

  8. Can children take Aggrenox?

    Aggrenox is not recommended for children or teenagers, especially those with viral illnesses like the flu or chickenpox, due to the risk of Reye’s syndrome, a serious condition that can cause liver and brain damage.

  9. Can I take Aggrenox during pregnancy or while breastfeeding?

    Aggrenox should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, especially during the last three months of pregnancy. If you are breastfeeding, consult your healthcare provider, as Aggrenox can pass into breast milk.

  10. Is it safe to consume alcohol while taking Aggrenox?

    Heavy alcohol use is discouraged while taking Aggrenox as it can increase the risk of stomach bleeding. If you consume three or more alcoholic drinks daily, discuss the potential risks with your healthcare provider.

  11. What should I do if I miss a dose or take an overdose of Aggrenox?

    If you miss a dose of Aggrenox, take it as soon as you remember unless it’s almost time for your next dose. In the case of an overdose, seek immediate medical attention. Symptoms of an overdose may include warmth, sweating, restlessness, weakness, dizziness, or a fast heart rate.

  12. How should Aggrenox be taken?

    Aggrenox is typically taken twice daily, once in the morning and once in the evening. The capsules should be swallowed whole, not crushed or chewed, and can be taken with or without food.

  13. What are the common side effects of taking Aggrenox?

    While many people taking Aggrenox do not experience severe side effects, some common ones include headache, diarrhea, abdominal pain, and dizziness. It’s important to contact your healthcare provider if side effects are severe or persistent.

  14. Can Aggrenox be taken with other medications?

    Aggrenox may interact with various medications, including blood thinners, medicines for high blood pressure, heart disease, and NSAIDs, increasing the risk of bleeding. Always consult your healthcare provider before combining Aggrenox with other treatments.

  15. Who should not take Aggrenox?

    Individuals allergic to aspirin or dipyridamole, those with a history of asthma combined with runny nose and nasal polyps, and patients allergic to NSAIDs should avoid Aggrenox. It’s also crucial not to give Aggrenox to children or teenagers with a viral illness due to the risk of Reye’s syndrome.

  16. What exactly is Aggrenox used for?

    Aggrenox is a medication that combines aspirin and dipyridamole. It’s used to reduce the risk of stroke in people who have had transient ischemic attacks (TIAs) or a previous stroke due to a blood clot. This dual-action helps prevent platelets in your blood from sticking together and forming clots.

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References
Aggrenox [package insert].Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals; 2012.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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