FAQ

The points given below are to be kept in mind before starting Zepbound

• Don't use Zepbound if you or anyone in your family has ever had a type of thyroid cancer called MTC or if you have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• It could lead to thyroid tumors, including cancer. If you notice a lump or swelling in your neck, have trouble swallowing, sound hoarse, or experience shortness of breath, tell your doctor. These could be signs of thyroid cancer. In studies with rats, Zepbound and similar medicines caused thyroid tumors, including thyroid cancer. We're not sure if Zepbound can do the same in people or cause a type of thyroid cancer called medullary thyroid carcinoma (MTC).

Do not use Zepbound if:

• You or anyone in your family has had a certain type of thyroid cancer called MTC or you have a medical condition called MEN 2 that affects your endocrine system.
• You have had a severe allergic reaction to tirzepatide or any of the substances used in Zepbound. You can find a list of these ingredients at the end of this Medication Guide.

Before you start using Zepbound, make sure to talk to your healthcare provider about your health and any concerns you have. Here are some important things to discuss:

• Medical Conditions: Let your healthcare provider know if you have or had any issues with your pancreas or kidneys.
• Stomach Problems: Inform your healthcare provider if you have severe stomach problems, like slow emptying of your stomach (gastroparesis) or difficulties digesting food.
• Diabetic Retinopathy: Mention if you have a history of diabetic retinopathy.
• Pregnancy: If you are pregnant or planning to have a child, it's essential to tell your healthcare provider because Zepbound may be harmful to an unborn baby.
1. Pregnancy Exposure Registry: There's a registry for pregnant women who have used Zepbound. This registry aims to collect information about your and your baby's health. You can join this registry or get more information by contacting Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).
2. Birth Control: If you take birth control pills by mouth, they may not work as well while using Zepbound. Your healthcare provider may suggest an alternative birth control method for four weeks after starting Zepbound or after any dose increase. Discuss the right birth control options for you with your healthcare provider.
• Breastfeeding: If you are breastfeeding or planning to breastfeed, let your healthcare provider know. It's unclear if Zepbound passes into breast milk, so your healthcare provider can guide you on the best way to feed your baby while using Zepbound.
• Medications: Inform your healthcare provider about all the medicines you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Zepbound can affect how some medicines work, and other medicines may impact how Zepbound works.

Remember to keep a list of all the medicines you take to share with your healthcare provider and pharmacist when you start a new medication. This information will help ensure your safety while using Zepbound.

Zepbound is administered by injecting it just under the skin. You can inject it in your stomach (abdomen), thigh, or upper arm. These are the most preferred three sites where you can inject Zepbound.

You should use Zepbound once a week, and you can use it at any time of the day that is convenient for you.

Yes, you have the flexibility to select a different day of the week for your Zepbound doses as long as you ensure that there is a gap of at least 3 days between each dose. This means you can adjust your dosing schedule to better suit your preferences or schedule, while still following the recommended dosing interval.

If you miss a dose of Zepbound medicine, follow these steps:

• If you remember within 4 days (96 hours) of missing a dose:
1. Take the missed dose when you remember.
2. If more than 4 days (96 hours) have passed since you missed a dose.
• Do not take the missed dose.
1. You should take your next dose on your regular scheduled day.
2. Never take two doses of Zepbound within a gap of 3 days (72 hours).

It's essential to stick to your prescribed schedule for taking Zepbound to ensure its effectiveness.

You can choose to eat something before taking it, or you can take it on an empty stomach. It's up to you.

You should change the injection site. You can still use the same part of your body, but make sure you pick a different spot in that part. Don't keep using the same spot every time you give yourself an injection.

If you overdose on Zepbound, you should immediately contact a Poison Center expert or seek emergency medical help.