Vytorin combines two cholesterol-lowering medications, ezetimibe and simvastatin, into one tablet. It’s prescribed primarily to treat various forms of high cholesterol, including primary hyperlipidemia (both familial and nonfamilial), mixed hyperlipidemia, and homozygous familial hypercholesterolemia (HoFH). By addressing these conditions, Vytorin aids in reducing the risk of heart attacks and strokes.