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Is it safe to administer Humulin R insulin when it's cold?

Humulin R works just as well whether it's cold or not when you inject it. However, some people have said that it can hurt when they inject cold insulin. So, if you keep your Humulin R in the fridge and want to make it less painful, take it out and let it warm up to room temperature before you use it. That should help reduce any discomfort when you inject it.