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How does Skyrizi work?

Skyrizi contains risankizumab-rzaa, an IL-23 antagonist. It binds to the p19 subunit of the IL-23 protein, inhibiting its interaction with the IL-23 receptor. This helps reduce inflammation by preventing the release of pro-inflammatory cytokines and chemokines, thereby improving symptoms associated with psoriasis, psoriatic arthritis, and Crohn’s disease.