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How does Entresto work?

Entresto's formulation consists of sacubitril, which acts as a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Sacubitril helps prevent the breakdown of substances that dilate blood vessels and reduce sodium levels, while valsartan blocks the effects of a hormone that can tighten blood vessels. Together, they help lower blood pressure and reduce strain on the heart.