Zoloft should not be taken with certain medications, including monoamine oxidase inhibitors (MAOIs), sertraline-containing medicines, pimozide, and liquid Antabuse. It's essential to inform your healthcare provider about all your medications, including prescriptions, OTC drugs, vitamins, and supplements, as some may interact with Zoloft. Do not start or stop any medication while taking Zoloft without consulting your healthcare provider first.