Treximet (Sumatriptan Succinate/ Naproxen Sodium)

 

 

Treximet (Sumatriptan Succinate/ Naproxen Sodium)

Treximet combines two proven ingredients, sumatriptan succinate and naproxen sodium, to provide fast and sustained relief from migraine attacks. Sumatriptan targets migraine pain by narrowing blood vessels around the brain, while naproxen reduces inflammation that contributes to headache symptoms. Together, they deliver dual-action relief to help you get back to your day sooner.

Why Choose Treximet (Sumatriptan Succinate/ Naproxen Sodium)?

• Provides rapid relief from migraine pain and associated symptoms such as nausea, sensitivity to light, and sound
• Longer-lasting effect compared to single-ingredient treatments
• Convenient tablet form for use at the first sign of a migraine
• Combines two mechanisms of action for enhanced effectiveness
• Can reduce the need for additional pain medication

How to Use Treximet (Sumatriptan Succinate/ Naproxen Sodium)?

• Take one tablet at the first sign of migraine symptoms.
• If the headache returns, a second dose may be taken after 2 hours, only if prescribed by your doctor.
• Do not exceed two doses in 24 hours.
• Swallow the tablet whole with water; do not crush or chew it.
• Avoid using Treximet for more than 10 days per month to reduce the risk of medication overuse headaches.
• Always consult your healthcare provider before starting or adjusting your dose.

Important Safety Information about Treximet

• Not recommended for patients with heart disease, uncontrolled high blood pressure, or a history of stroke.
• Avoid use if you are allergic to NSAIDs (e.g., aspirin, ibuprofen) or triptans.
• May increase the risk of heart attack or stroke, especially with long-term use.
• Should not be used in combination with other triptan or ergot-type migraine drugs.
• Tell your doctor about all medications you are taking, especially antidepressants (SSRIs/SNRIs), blood thinners, or diuretics.
• Avoid alcohol while taking Treximet, as it may worsen side effects.

Fact Table

 

Facts	Details
Brand Name	Treximet
Generic Name	Sumatriptan Succinate / Naproxen Sodium
Drug Class	Migraine therapy; combination of a triptan (Sumatriptan) and NSAID (Naproxen Sodium)
Dosage Form	Oral tablet (film-coated)
Intended Use	Acute treatment of migraine attacks with or without aura in adults and adolescents (12 years and older)
Mechanism of Action	– Sumatriptan: Stimulates serotonin (5-HT₁) receptors in cranial blood vessels, causing vasoconstriction and reducing inflammation. – Naproxen Sodium: Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin formation and relieving pain and inflammation. – The combination targets both neurovascular inflammation and pain pathways, providing faster and longer-lasting migraine relief.
Onset of Action	Typically within 1–2 hours after oral administration
Duration of Effect	Relief can last up to 24 hours, with a reduced risk of migraine recurrence compared to sumatriptan alone
Administration Instructions	– Take orally with water. – May be taken with or without food. – Do not split, crush, or chew tablets.
Storage Conditions	Store at 20°C–25°C (68°F–77°F); protect from moisture and light.
Key Benefits	– Dual-action formula offers faster relief and longer duration of migraine control. – Reduces recurrence rate of migraines. – Provides both pain relief and inflammation reduction in a single dose.
Warnings & Precautions	– Not for preventive migraine treatment. – Contraindicated in patients with ischemic heart disease, uncontrolled hypertension, cerebrovascular syndromes, or peripheral vascular disease. – Avoid in patients with NSAID-induced asthma, peptic ulcers, or GI bleeding. – Risk of cardiovascular thrombotic events and gastrointestinal bleeding with prolonged NSAID use. – Avoid use with other triptans or ergot-type medications within 24 hours.
Drug Interactions	– SSRIs/SNRIs: Risk of serotonin syndrome. – Anticoagulants / Antiplatelet agents: Increased bleeding risk. – Other NSAIDs: Increased GI and renal side effects. – MAO inhibitors: Contraindicated. – Lithium or diuretics: May alter efficacy or toxicity.
Common Side Effects	– Dizziness or drowsiness – Nausea – Dry mouth – Tingling sensation or warmth – Stomach discomfort or indigestion – Fatigue

Common Side Effects

Like all medications, Treximet (Sumatriptan Succinate/ Naproxen Sodium) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Dizziness or drowsiness
• Nausea or stomach discomfort
• Heartburn or indigestion
• Flushing or warmth sensation
• Dry mouth or fatigue

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Treximet (Sumatriptan Succinate/ Naproxen Sodium)?

You can order Treximet (Sumatriptan Succinate/ Naproxen Sodium) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.