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Seroquel XR (Quetiapine Fumarate)
Seroquel XR (Quetiapine Fumarate)
Seroquel XR (Quetiapine Fumarate) is an extended-release medication primarily used to treat mental health conditions such as schizophrenia, bipolar disorder, and major depressive disorder. This atypical antipsychotic works by balancing neurotransmitters like dopamine and serotonin in the brain, which helps stabilize mood, reduce hallucinations, and improve overall mental clarity.
Why Choose Seroquel XR (Quetiapine Fumarate)?
- Effective Symptom Relief: Alleviates symptoms of schizophrenia, bipolar disorder, and major depressive disorder by addressing chemical imbalances in the brain.
- Mood Stabilization: Helps regulate mood swings in bipolar disorder and supports mood improvement in depressive episodes.
- Extended Release: Designed for steady, long-lasting effects with once-daily dosing for better adherence and consistent symptom control.
- Reduces Psychotic Symptoms: Aids in reducing hallucinations, disorganized thinking, and delusions, promoting a clearer thought process.
- Supports Overall Mental Well-being: Enhances quality of life by managing the disruptive symptoms associated with various mental health conditions.
How to Use Seroquel XR (Quetiapine Fumarate)?
- Consult with Your Healthcare Provider: Ensure this medication is right for you by discussing any medical history, current medications, and mental health needs with your doctor.
- Follow Prescribed Dosage: Take Seroquel XR exactly as prescribed, typically once daily in the evening, without crushing or chewing the tablet.
- Monitor for Reactions: Stay mindful of any unusual side effects, especially when starting or adjusting the dose, and inform your healthcare provider promptly.
- Avoid Alcohol: Alcohol can increase side effects such as dizziness, drowsiness, and impaired thinking. It’s best to avoid alcoholic beverages while on Seroquel XR.
- Stay Consistent: Try to take the medication at the same time each day for optimal benefits.
- Do Not Abruptly Stop: Stopping Seroquel XR suddenly may lead to withdrawal symptoms; consult your doctor if you need to discontinue or adjust your dose.
Important Safety Information about Seroquel XR
- Not Suitable for Everyone: Inform your doctor if you have liver or kidney issues, cardiovascular conditions, or a history of seizures.
- Risk of Drowsiness and Dizziness: May impair your ability to drive or operate machinery; avoid these activities until you know how Seroquel XR affects you.
- Increased Risk in Older Adults: Especially those with dementia-related conditions, due to a higher likelihood of cardiovascular or fatal side effects.
- Monitor Blood Sugar and Lipid Levels: Regular blood tests may be advised as Seroquel XR can affect blood sugar, cholesterol, and triglyceride levels.
Fact Table
| Facts | Details |
| Brand Name | Seroquel XR |
| Generic Name | Quetiapine Fumarate |
| Drug Class | Atypical Antipsychotic |
| Formulation | Extended-Release Tablets |
| Available Strengths | 50 mg, 150 mg, 200 mg, 300 mg, 400 mg |
| Mechanism of Action | Seroquel XR primarily acts on neurotransmitters in the brain, particularly dopamine (D2) and serotonin (5-HT2A) receptors. |
| Primary Indications | – Schizophrenia – Bipolar Disorder (both manic and depressive episodes) – Major Depressive Disorder (as an adjunct treatment) |
| Dosage & Administration | – Taken once daily, typically in the evening. – Swallow tablets whole; do not split, chew, or crush. – Dosage may be adjusted based on individual response and tolerance. |
| Common Side Effects | – Drowsiness or sedation – Dry mouth – Constipation – Dizziness or light-headedness |
| Warnings & Precautions | – Risk of metabolic syndrome, including weight gain, high blood sugar, and increased cholesterol – Monitor for signs of hyperglycemia, especially in patients with diabetes – Caution with activities requiring alertness (e.g., driving) due to potential sedation – Regular monitoring of blood pressure in patients prone to low blood pressure |
| Drug Interactions | – May interact with other CNS depressants (e.g., alcohol, benzodiazepines) leading to increased sedation – Caution with drugs that prolong QT interval (e.g., certain antibiotics and antiarrhythmics) – CYP3A4 inhibitors (e.g., ketoconazole) may increase quetiapine levels; CYP3A4 inducers (e.g., phenytoin) may decrease quetiapine levels |
| Pregnancy Category | Category C (Risk to the fetus cannot be ruled out; consult with a healthcare provider) |
| Breastfeeding | – May pass into breast milk; not recommended for breastfeeding mothers |
| Storage Instructions | – Store at room temperature between 20-25°C (68-77°F), away from moisture and light |
| FDA Approval Date | Extended-release formulation approved in 2007 |
Common Side Effects
Like all medications, Seroquel XR (Quetiapine Fumarate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Drowsiness
- Dry Mouth
- Weight Gain
- Constipation
- Dizziness and Lightheadedness
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Seroquel XR (Quetiapine Fumarate)?
You can order Seroquel XR (Quetiapine Fumarate) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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