Salazopyrin EN (Sulfasalazine)

Salazopyrin EN
Sulfasalazine

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Generic Equivalents   What's the difference?
Sulfasalazine Delayed Release
Sulfasalazine

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Salazopyrin EN (Sulfasalazine)

Salazopyrin EN (Sulfasalazine) is a prescription medication designed to manage and treat inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease, as well as rheumatoid arthritis. This enteric-coated tablet reduces inflammation in the gut and joints by inhibiting substances that trigger the body’s immune response.

Why Choose Salazopyrin EN (Sulfasalazine)?

  • Effective Symptom Relief: Helps manage abdominal pain, diarrhea, and joint discomfort associated with inflammatory conditions.
  • Dual-Action Formula: Targets inflammation both in the gastrointestinal tract and joints for comprehensive relief.
  • Enteric Coating: Ensures the medication is gentle on the stomach by dissolving in the intestines.
  • Proven Track Record: Trusted by healthcare providers for long-term inflammatory disease management.

How to Use Salazopyrin EN (Sulfasalazine)?

  • Follow Prescription Guidelines: Always take Salazopyrin EN exactly as prescribed by your healthcare provider.
  • Take with Food or Water: To avoid stomach upset, swallow the tablet whole during or after meals.
  • Stay Hydrated: Drink plenty of fluids while taking this medication to minimize the risk of kidney-related side effects.
  • Adhere to Regular Timing: Take doses at the same times daily to maintain consistent medication levels.
  • Do Not Skip Doses: Missing doses may reduce the effectiveness of the treatment.

Important Safety Information about Salazopyrin EN

  • Allergic Reactions: Do not use if you are allergic to sulfasalazine, sulfa drugs, or salicylates like aspirin.
  • Monitor Blood Counts: Regular blood tests are recommended to check for changes in liver function or blood cell levels.
  • Kidney or Liver Issues: Notify your doctor about any pre-existing kidney or liver conditions before starting treatment.
  • Sun Sensitivity: Avoid prolonged sun exposure, as this medication may increase your skin’s sensitivity to sunlight.

Fact Table

 

Facts Details
Generic Name Sulfasalazine
Brand Name Salazopyrin EN
Medication Type Anti-inflammatory (Aminosalicylate derivative)
Form Enteric-coated tablets
Strengths Available Typically available in 500 mg dosage
Prescription Required Yes
Uses – Treatment of inflammatory bowel diseases (Ulcerative Colitis, Crohn’s Disease) – Management of rheumatoid arthritis
How It Works – Reduces inflammation by inhibiting immune system chemicals that cause tissue damage – Acts locally in the intestines and systemically for joint inflammation
Key Benefits – Reduces gastrointestinal and joint inflammation – Minimizes symptoms such as pain, diarrhea, and swelling – Helps maintain remission in inflammatory bowel diseases
Administration Oral (swallow whole, do not crush or chew)
Dosage Instructions – Typically taken 2-4 times daily, as prescribed – Adjusted based on condition severity and patient tolerance
Onset of Action – Effects on symptoms may take several days to weeks
Common Side Effects – Nausea, vomiting, loss of appetite – Headache – Rash or skin itching – Fatigue – Orange-colored urine (harmless)
Precautions – Avoid if allergic to sulfa drugs or salicylates – Monitor liver, kidney, and blood function regularly during treatment – Use with caution in patients with liver or kidney impairment
Drug Interactions – May interact with anticoagulants, folic acid, and other medications – Inform your doctor of all medications you are taking
Storage Instructions – Store at room temperature (15-25°C / 59-77°F) – Keep away from moisture and direct sunlight
Availability Prescription-only, widely available

Common Side Effects

Like all medications, Salazopyrin EN (Sulfasalazine) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Nausea
  • Vomiting
  • Loss of appetite.
  • Headache
  • Rash or Itching
  • Fatigue

If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Salazopyrin EN (Sulfasalazine)?

You can order Salazopyrin EN (Sulfasalazine) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. What is Sulfasalazine used for?

    Sulfasalazine is primarily used to treat inflammatory bowel diseases like ulcerative colitis and Crohn’s disease. It also helps manage rheumatoid arthritis and sometimes psoriatic arthritis. This medication works by reducing inflammation, which helps relieve symptoms like pain, swelling, and digestive issues.

  2. How does Sulfasalazine work?

    Sulfasalazine belongs to a group of drugs called disease-modifying anti-rheumatic drugs (DMARDs). It reduces inflammation in the body, particularly in the joints and intestines, by suppressing the immune system’s response, thereby alleviating symptoms and preventing further damage.

  3. When will I start noticing the effects of Sulfasalazine?

    Sulfasalazine doesn’t work immediately. It may take anywhere from 1 to 3 months to notice an improvement in symptoms, particularly for conditions like rheumatoid arthritis. Patience is key, as the medication needs time to build up in your system.

  4. What are the common side effects of Sulfasalazine?

    Common side effects of Sulfasalazine are vomiting, nausea, loss of appetite, headache, and changes in urine color (which may turn orange). You might also experience dizziness, stomach pain, or a mild rash. If side effects occur, be sure to speak with your doctor as soon as you can.

  5. Can I take Sulfasalazine if I’m pregnant or breastfeeding?

    Generally, Sulfasalazine is considered safe during pregnancy, but it may lower folic acid levels, so you might need to take a supplement. It’s usually safe during breastfeeding, though small amounts can pass into breast milk. Always discuss with your doctor if you’re pregnant, planning to become pregnant, or breastfeeding.

  6. How should I take Sulfasalazine?

    Sulfasalazine comes in tablet, liquid, and suppository forms. It’s usually taken with food and a full glass of water to reduce stomach upset. Make sure you swallow the tablet whole. Ensure you follow your doctor’s dosage instructions carefully.

  7. Can I drink alcohol while taking Sulfasalazine?

    Moderate alcohol consumption is generally safe while taking Sulfasalazine, but it’s best to keep within recommended limits. Excessive drinking could potentially increase the risk of liver damage or other complications.

  8. Will Sulfasalazine affect my fertility?

    Sulfasalazine can reduce sperm count in men, which usually returns to normal a few months after stopping the medication. It doesn’t generally affect fertility in women, but if you’re trying to conceive, discuss it with your doctor.

  9. Can I take other medications with Sulfasalazine?

    Sulfasalazine can interact with certain other medications, including some diabetes drugs, antibiotics, and folic acid. Ensure your doctor is aware of all the medications you use.

  10. Can I stop taking Salazopyrin EN if I feel better?

    Do not stop taking Salazopyrin EN without consulting your doctor. Stopping suddenly can lead to a flare-up of symptoms. Your doctor will guide you on how to taper off the medication safely if needed.

  11. Is Salazopyrin EN safe for everyone?

    This medication is not suitable for people who are allergic to sulfasalazine, sulfa drugs, or salicylates. It should not be used by individuals with certain medical conditions like porphyria, severe liver or kidney disease, or intestinal or urinary blockages. Always consult your doctor to ensure it is safe for you.

  12. What precautions should I take while using Salazopyrin EN?

    Stay hydrated to avoid the formation of crystals in your urine. Protect your skin from the sun as this medication can increase sun sensitivity. Regular blood tests are required to monitor your liver function, kidney function, and blood cell counts due to potential side effects.

  13. How should I take Salazopyrin EN?

    It is usually prescribed in oral tablet form and should be taken with food to reduce stomach upset. The tablets must not be crushed or chewed but swallowed whole. Your doctor will advise on the correct dosage and frequency based on your specific condition.

  14. Can Salazopyrin EN interact with other medications?

    Yes, Salazopyrin EN can interact with several types of medications, including digoxin, folic acid supplements, and certain antirheumatic drugs like methotrexate. It’s crucial to inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.

  15. What are the potential side effects of taking Salazopyrin EN?

    Common side effects include headache, nausea, vomiting, and rash. It can also cause dizziness and decreased appetite. More serious side effects might include severe allergic reactions, liver damage, kidney damage, and blood disorders. It’s important to monitor for symptoms and discuss any concerns with your doctor.

  16. How does Salazopyrin EN work?

    Salazopyrin EN contains sulfasalazine, which belongs to a class of medications called anti-inflammatories. It works by suppressing the immune system and reducing inflammation in the joints and digestive system.

  17. What is Salazopyrin EN used for?

    Salazopyrin EN is used to treat and manage inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease, as well as rheumatoid arthritis. It helps by reducing inflammation and managing symptoms.

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References
Sulfasalazine [package insert].New York, NY: Pfizer; 2009.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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