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Jentadueto (Linagliptin / Metformin Hydrochloride)
Jentadueto (Linagliptin / Metformin Hydrochloride)
Jentadueto combines two active ingredients, Linagliptin, and Metformin Hydrochloride, to help manage blood sugar levels in adults with type 2 diabetes. Linagliptin is a DPP-4 inhibitor that increases insulin release after meals by prolonging the action of hormones that regulate glucose. Metformin works by reducing glucose production in the liver and improving insulin sensitivity. Together, they offer a dual approach to controlling blood sugar levels effectively.
Why Choose Jentadueto (Linagliptin / Metformin Hydrochloride)?
- Helps reduce blood sugar levels in individuals with type 2 diabetes
- Provides a combined mechanism that addresses both insulin secretion and glucose production
- May assist in achieving better blood sugar control than single-medication therapy
- Supports long-term management of type 2 diabetes when used with proper diet and exercise
How to Use Jentadueto (Linagliptin / Metformin Hydrochloride)?
- Take Jentadueto as prescribed by your healthcare provider, typically once or twice daily with meals
- Swallow the tablet whole with water; do not crush or chew
- Consistent timing for doses can help maximize effectiveness
- Follow your healthcare provider’s advice on diet and physical activity alongside medication
Important Safety Information about Jentadueto
- Store at room temperature, away from moisture and direct light
- Regularly monitor blood sugar levels to ensure the medication’s effectiveness
- Avoid alcohol, as it can increase the risk of lactic acidosis
- Inform your doctor of any kidney, liver, or heart conditions before starting Jentadueto
- Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding
Fact Table
| Facts | Details |
| Generic Name | Linagliptin / Metformin Hydrochloride |
| Brand Name | Jentadueto |
| Drug Class | Antidiabetic Combination: DPP-4 Inhibitor (Linagliptin) and Biguanide (Metformin) |
| Indication | Type 2 Diabetes Mellitus: Used as an adjunct to diet and exercise to improve glycemic control in adults. |
| Mechanism of Action | – Linagliptin: Inhibits DPP-4 enzyme, increasing incretin levels (GLP-1 and GIP) which help regulate glucose by enhancing insulin secretion and suppressing glucagon. – Metformin: Decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity. |
| Dosage Forms | Tablets |
| Recommended Dosage | Twice daily with meals. Dose adjusted based on patient’s prior therapy, effectiveness, and tolerability. |
| Maximum Dosage | 5 mg Linagliptin / 2000 mg Metformin HCl per day. |
| Common Side Effects | – Diarrhea – Nausea – Vomiting – Upper respiratory tract infection – Hypoglycemia (especially when combined with sulfonylureas or insulin) |
| Precautions | – Monitor renal function regularly. – Avoid in patients with liver disease or high alcohol consumption. – Risk of Vitamin B12 deficiency with long-term use. |
| Drug Interactions | – Alcohol (increases risk of lactic acidosis). – Sulfonylureas and Insulin (increased risk of hypoglycemia). – Medications that impair renal function (e.g., NSAIDs). |
| Storage Instructions | Store at 25°C (77°F) with permitted excursions to 15°–30°C (59°–86°F). Protect from moisture. |
| FDA Approval | Yes (Approved in 2012) |
Common Side Effects
Like all medications, Jentadueto (Linagliptin / Metformin Hydrochloride) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Nausea
- Diarrhea
- Upset stomach
- Sore throat or stuffy nose
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Jentadueto (Linagliptin / Metformin Hydrochloride)?
You can order Jentadueto (Linagliptin / Metformin Hydrochloride) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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