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Imvexxy (Estradiol)
Imvexxy (Estradiol)
Imvexxy (Estradiol) is designed for postmenopausal women to treat moderate to severe vaginal and vulvar atrophy symptoms, such as dryness, itching, and irritation. The insert works by replenishing estrogen levels locally in the vaginal tissues, helping to restore natural moisture and maintain the health of the vaginal lining. This action alleviates discomfort and enhances comfort during daily activities.
Why Choose Imvexxy (Estradiol)?
- Provides relief from moderate to severe vaginal dryness, itching, and irritation associated with menopause.
- Supports the health and elasticity of the vaginal tissues, promoting natural hydration.
- Helps improve sexual comfort and overall vaginal health.
- Administered locally, ensuring targeted delivery with minimal systemic absorption.
- Discreet and easy-to-use softgel design for user convenience.
How to Use Imvexxy (Estradiol)?
- Wash your hands thoroughly before and after handling the insert.
- Remove the softgel from its blister pack carefully to avoid damage.
- Lie down or stand in a comfortable position and gently insert the softgel into the vagina as directed by your healthcare provider.
- Follow your doctor’s prescribed schedule, usually once daily for the first two weeks and then twice weekly as maintenance.
- Ensure consistent use to achieve optimal results.
Important Safety Information about Imvexxy
- Keep Imvexxy at room temperature, away from direct sunlight and moisture. Store in its original packaging until use.
- Inform your doctor if you have a history of blood clots, liver disease, or hormone-sensitive conditions such as breast cancer.
- Avoid use if you are allergic to estradiol or any of the insert’s ingredients.
- Regular check-ups are recommended to monitor treatment effectiveness and overall health.
- Do not use if you are pregnant or breastfeeding unless specifically advised by your healthcare provider.
Fact Table
| Facts | Details |
| Product Name | Imvexxy |
| Active Ingredient | Estradiol |
| Formulation Type | Vaginal softgel insert |
| Intended Use | Treatment of moderate to severe vaginal and vulvar atrophy symptoms due to menopause |
| Mechanism of Action | Locally releases estradiol in the vaginal tissues, replenishing estrogen and maintaining tissue health |
| Dosage Strengths | Available in 4 mcg and 10 mcg softgel inserts |
| Administration Route | Vaginal |
| Usage Schedule | – Initial: Once daily for 2 weeks – Maintenance: Twice weekly as directed by a doctor |
| Key Benefits | – Relieves dryness, itching, and irritation – Supports natural vaginal moisture – Improves comfort during daily and sexual activities |
| Onset of Action | Varies by individual; typically within a few weeks for symptom improvement |
| Duration of Therapy | As prescribed by a healthcare provider, based on individual response and symptom severity |
| Storage Instructions | Store at room temperature, away from light and moisture |
| Precautions | – Disclose medical history, especially of blood clots, liver disease, or hormone-sensitive cancers – Regular medical check-ups recommended during use |
| Contraindications | – Allergy to estradiol or any component of the product – Pregnancy and breastfeeding without doctor’s advice |
| Possible Drug Interactions | Inform your doctor of any other medications being taken, especially hormone therapies or anticoagulants |
| Common Side Effects | – Vaginal discharge – Headache – Abdominal discomfort – Nausea |
| Approval and Regulation | FDA-approved for use in the U.S. |
Common Side Effects
Like all medications, Imvexxy (Estradiol) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Mild irritation or discharge at the site of application.
- Headache or breast tenderness.
- Abdominal discomfort or bloating.
- Nausea or mild dizziness.
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Imvexxy (Estradiol)?
You can order Imvexxy (Estradiol) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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