Glucophage XR (Metformin Hydrochloride)
Glucophage XR (Metformin Hydrochloride)
Glucophage XR, containing the active ingredient Metformin Hydrochloride, is an oral antihyperglycemic medication used to control high blood sugar in people with type 2 diabetes. This extended-release formulation is designed to be taken once daily, offering a convenient dosing schedule.
Why Choose Glucophage XR (Metformin Hydrochloride)?
- Extended Blood Sugar Control: Provides effective glycemic control throughout the day with a once-daily dosage.
- Reduced Gastrointestinal Side Effects: The extended-release formulation is designed to minimize gastrointestinal discomfort, a common side effect of Metformin.
- Weight Neutral: Unlike some other diabetes medications, Glucophage XR does not typically cause weight gain.
- Improved Insulin Sensitivity: Helps improve your body’s response to insulin.
How to Use Glucophage XR (Metformin Hydrochloride)?
- Take Glucophage XR exactly as prescribed by your healthcare provider.
- Swallow tablets whole with an evening meal.
- Regular blood sugar monitoring is recommended.
- Do not crush, chew, or break the tablets.
Important Safety Information about Glucophage XR
- Not for treatment of type 1 diabetes or diabetic ketoacidosis.
- Inform your doctor about your complete medical history, especially kidney or liver problems.
- Avoid excessive alcohol intake as it may increase the risk of lactic acidosis.
- Store in a cool, dry place away from direct sunlight and out of reach of children.
Fact Table
Facts | Details |
Generic Name | Metformin Hydrochloride |
Brand Name | Glucophage XR |
Drug Class | Biguanide |
Indication | Management of type 2 diabetes mellitus |
FDA Approval | Initially approved in 1995 (for Metformin), the Extended-release version (Glucophage XR) was approved later |
Mechanism of Action | Decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization |
Administration Route | Oral |
Available Dosage Forms | Extended-release tablets: 500 mg, 750 mg, 1000 mg |
Common Dosage | Varies; typically starts at 500 mg once daily with the evening meal; gradually increased based on glycemic control and patient tolerance |
Maximum Dosage | Up to 2000 mg per day |
Contraindications | Severe renal impairment, metabolic acidosis, hypersensitivity to metformin |
Common Side Effects | Gastrointestinal symptoms (diarrhea, nausea/vomiting, flatulence), Vitamin B12 deficiency, lactic acidosis (rare but serious) |
Drug Interactions | May interact with diuretics, steroids, phenothiazines, thyroid products, oral contraceptives, and other drugs |
Precautions | Monitor renal function regularly; caution in patients with risk factors for lactic acidosis; temporarily discontinue before radiologic studies with contrast media |
Pregnancy Category | Category B (no evidence of risk in humans) |
Storage Recommendations | Store at 20 to 25°C (68 to 77°F); excursions permitted to 15 to 30°C (59 to 86°F) |
Common Side Effects
Like all medications, Glucophage XR (Metformin Hydrochloride) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Nausea
- Vomiting
- Diarrhea
- Gas
- Stomach pain
- Indigestion.
- Metallic Taste
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Glucophage XR (Metformin Hydrochloride)?
You can order Glucophage XR using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.