Gleevec (Imatinib Mesylate)

 

Gleevec (Imatinib Mesylate)

Gleevec (Imatinib Mesylate) is an oral prescription therapy used to treat certain types of cancers and blood disorders. It works by targeting specific proteins (tyrosine kinases) that signal cancer cells to grow, helping to slow or stop their spread. Gleevec is most commonly prescribed for chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST), and other rare conditions where abnormal cell growth is driven by these proteins.

Why Choose Gleevec (Imatinib Mesylate)?

• Specifically designed to block cancer cell growth signals
• Effective in treating chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST)
• Helps reduce tumor size and progression in eligible patients
• Taken orally, making it convenient compared to intravenous treatments
• Clinically proven to improve long-term survival outcomes in CML patients

How to Use Gleevec (Imatinib Mesylate)?

• Take exactly as prescribed by your healthcare provider
• Swallow tablets with a large glass of water and food to reduce stomach upset
• Do not crush or chew tablets unless advised by your doctor
• Take doses at the same time each day to maintain consistent levels
• Inform your doctor of all medications, supplements, or herbal products you are taking
• Keep regular medical appointments for blood tests and progress monitoring

Important Safety Information about Gleevec

• Not suitable for patients allergic to imatinib or any of its ingredients
• May interact with other medicines, including certain antibiotics, antifungals, and blood thinners
• Use with caution if you have liver, kidney, or heart conditions
• Women should avoid pregnancy while taking Gleevec and use effective contraception
• Regular monitoring is required for liver function, blood counts, and heart health
• Do not stop taking Gleevec without consulting your doctor, even if symptoms improve

Fact Table

 

Facts	Details
Generic Name	Imatinib Mesylate
Brand Name(s)	Gleevec
Drug Class	Tyrosine kinase inhibitor (TKI)
Dosage Forms	Oral tablets (film-coated)
Route of Administration	Oral (by mouth)
Indications / Uses	– Chronic Myeloid Leukemia (CML) – Acute Lymphoblastic Leukemia (Ph+ ALL) – Gastrointestinal Stromal Tumors (GIST) – Myelodysplastic/Myeloproliferative diseases (MDS/MPD) – Hypereosinophilic Syndrome (HES) / Chronic Eosinophilic Leukemia (CEL) – Dermatofibrosarcoma Protuberans (DFSP)
Mechanism of Action	Selectively inhibits BCR-ABL and other tyrosine kinases, blocking signals that promote cancer cell growth and survival
Administration Notes	– Take with a meal and a large glass of water – Do not crush or chew tablets – Take at the same time daily
Common Side Effects	Nausea, vomiting, diarrhea, fluid retention (edema), muscle cramps, rash, fatigue, headache
Contraindications	Known hypersensitivity to imatinib or any component of the formulation
Drug Interactions	– CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase imatinib levels – CYP3A4 inducers (e.g., rifampin, phenytoin, St. John’s Wort) may decrease effectiveness – May interact with warfarin, acetaminophen, and other hepatically metabolized drugs
Monitoring Parameters	– CBC with differential (blood counts) – Liver function tests (LFTs) – Renal function – Signs of edema, fluid retention, or cardiac dysfunction
Storage Conditions	Store at 20-25°C (68-77°F); protect from moisture and light

Common Side Effects

Like all medications, Gleevec (Imatinib Mesylate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Nausea, vomiting, or upset stomach
• Diarrhea
• Swelling around eyes, hands, or feet (edema)
• Muscle cramps or joint pain
• Fatigue or weakness

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Gleevec (Imatinib Mesylate)?

You can order Gleevec (Imatinib Mesylate) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.