Eldepryl (Selegiline Hydrochloride)

 

Eldepryl (Selegiline Hydrochloride)

Eldepryl (Selegiline Hydrochloride) is a prescription medicine used to help manage the symptoms of Parkinson’s disease. It belongs to a class of medicines known as monoamine oxidase-B (MAO-B) inhibitors. By blocking the breakdown of dopamine in the brain, Eldepryl supports better motor control and helps reduce symptoms such as stiffness, tremors, and difficulty with movement. It is often used alongside levodopa or other therapies to enhance treatment effectiveness.

Why Choose Eldepryl (Selegiline Hydrochloride)?

• Helps improve motor function and movement in Parkinson’s disease.
• Reduces the wearing-off effects of levodopa treatment.
• Supports better control of symptoms like stiffness, tremors, and slowed movements.
• May help improve the quality of life and independence in daily activities.
• Convenient oral capsule form for easy use.

How to Use Eldepryl (Selegiline Hydrochloride)?

• Take exactly as prescribed by your healthcare provider.
• Usually taken with breakfast and lunch, avoid late-day doses to prevent insomnia.
• Swallow capsules whole with water; do not crush or chew.
• Always follow your doctor’s advice when combining with other Parkinson’s medicines.
• Store at room temperature, away from moisture and heat.

Important Safety Information about Eldepryl

• Do not take Eldepryl if you are allergic to Selegiline or similar medicines.
• Avoid using with certain antidepressants, pain medicines, or other MAO inhibitors; serious interactions may occur.
• Inform your doctor of all medications, supplements, and herbal products you are taking.
• May increase sensitivity to foods containing high levels of tyramine (aged cheese, cured meats, red wine), which can cause a sudden rise in blood pressure.
• Use caution if you have a history of high blood pressure, heart disease, liver problems, or psychiatric conditions.
• Not recommended during pregnancy or breastfeeding unless directed by a doctor.

Fact Table

 

Facts	Details
Brand Name	Eldepryl
Generic Name	Selegiline Hydrochloride
Drug Class	Monoamine Oxidase Inhibitor (MAOI), selective for MAO-B at recommended doses
Formulation	Oral tablets (commonly 5 mg)
Route of Administration	Oral
Indication(s)	– Adjunct therapy in the management of Parkinson’s disease (with levodopa/carbidopa) – Sometimes used off-label for major depressive disorder (in different formulations like transdermal patch)
Mechanism of Action	Selectively inhibits monoamine oxidase type B (MAO-B), an enzyme responsible for breaking down dopamine in the brain. Inhibition leads to increased dopamine levels, improving motor symptoms in Parkinson’s disease.
Typical Dosage	– Parkinson’s disease (oral tablet): 5 mg twice daily (morning and noon) – Maximum: 10 mg/day – Often used with levodopa/carbidopa to reduce “wearing-off” effects
Onset of Action	Within days to weeks, with clinical benefit more apparent after continued use
Key Benefits	– Enhances and prolongs levodopa effectiveness – Improves motor function and daily activity performance – Reduces “off” periods in Parkinson’s therapy
Common Side Effects	– Insomnia (if taken later in the day) – Nausea – Dizziness – Dry mouth – Headache
Contraindications	– Concomitant use with meperidine, tramadol, methadone, propoxyphene – Concomitant use with SSRIs, SNRIs, tricyclic antidepressants (risk of serotonin syndrome) – Pheochromocytoma
Drug Interactions	– Levodopa (enhanced effects) – Antidepressants (SSRIs, SNRIs, TCAs, etc.) – risk of serotonin syndrome – Sympathomimetic drugs (e.g., pseudoephedrine) – risk of hypertensive crisis – Tyramine-rich foods at higher doses (aged cheese, cured meats, red wine)
Special Precautions	– Take early in the day to avoid insomnia – Monitor blood pressure regularly – Use cautiously in elderly due to fall risk – Avoid abrupt discontinuation
Storage	Store at room temperature, away from moisture and heat

Common Side Effects

Like all medications, Eldepryl (Selegiline Hydrochloride) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

• Nausea or upset stomach
• Dizziness or lightheadedness
• Dry mouth
• Trouble sleeping (insomnia)
• Headache

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Eldepryl (Selegiline Hydrochloride)?

You can order Eldepryl (Selegiline Hydrochloride) using these methods on our website:

1. Order Online
2. Order by Phone
3. Order by Fax
4. Order your refills

Visit our How to order page.