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Avalide (Irbesartan/ Hydrochlorothiazide)
Avalide (Irbesartan/ Hydrochlorothiazide)
Avalide is a combination medication that combines Irbesartan, an angiotensin receptor blocker (ARB), with Hydrochlorothiazide, a diuretic. This dual-action formula effectively manages high blood pressure (hypertension) by relaxing blood vessels and helping your body eliminate excess salt and water. Avalide can also reduce the risk of strokes and heart-related issues when taken as prescribed.
Why Choose Avalide (Irbesartan/ Hydrochlorothiazide)?
- Effective Blood Pressure Control: Combines two mechanisms to effectively lower and stabilize blood pressure.
- Stroke Risk Reduction: Helps reduce the chances of stroke in hypertensive patients.
- Convenient Dosing: Combines two medications in one pill for ease of use.
- Heart Health Support: Improves cardiovascular health by lowering strain on the heart.
How to Use Avalide (Irbesartan/ Hydrochlorothiazide)?
- Follow the Prescription: Take Avalide exactly as prescribed by your healthcare provider.
- Take Once Daily: Preferably at the same time each day for consistent blood levels.
- With or Without Food: Avalide can be taken with meals or on an empty stomach.
- Hydrate Adequately: Drink sufficient water unless otherwise advised by your doctor.
- Avoid Missing Doses: Stick to your schedule and set reminders if needed.
Important Safety Information about Avalide
- Avoid During Pregnancy: Not recommended for pregnant women, as it can harm an unborn baby.
- Regular Monitoring: Blood pressure and kidney function should be regularly checked while on Avalide.
- Watch for Electrolyte Imbalance: Monitor potassium and sodium levels to avoid complications.
- Drug Interactions: Inform your doctor about other medications or supplements you’re taking.
- Allergic Reactions: Discontinue use and seek immediate help if you experience swelling, rash, or difficulty breathing.
Fact Table
| Facts | Details |
| Generic Name | Irbesartan / Hydrochlorothiazide |
| Brand Name | Avalide |
| Drug Class | – Angiotensin II Receptor Blocker (ARB) – Thiazide Diuretic |
| Formulation | Oral Tablet |
| Available Strengths | – 150 mg / 12.5 mg – 300 mg / 12.5 mg – 300 mg / 25 mg |
| Primary Use | Treatment of high blood pressure (hypertension) |
| Mechanism of Action | – Irbesartan: Blocks angiotensin II receptors, relaxing blood vessels. – Hydrochlorothiazide: Removes excess salt and water through urination. |
| Onset of Action | Approximately 2 hours after oral administration |
| Peak Effect | 3–6 hours |
| Duration of Effect | 24 hours (once-daily dosing) |
| Recommended Dosage | – Starting dose: 150 mg / 12.5 mg once daily – Maximum dose: 300 mg / 25 mg once daily |
| Administration Instructions | – Take orally, with or without food. – Maintain consistent timing daily. |
| Common Side Effects | – Dizziness or lightheadedness – Increased urination – Fatigue or weakness – Nausea |
| Drug Interactions | – Lithium (increased toxicity risk) – Other blood pressure medications (risk of low BP) – NSAIDs (reduced efficacy) – Potassium supplements or potassium-sparing diuretics |
| Storage Instructions | – Store at room temperature (20–25°C or 68–77°F). – Keep away from moisture and direct sunlight. |
Common Side Effects
Like all medications, Avalide (Irbesartan/ Hydrochlorothiazide) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Dizziness or lightheadedness, especially during the initial days of treatment.
- Increased frequency of urination due to the diuretic component.
- Fatigue or weakness.
- Mild nausea or stomach upset.
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Avalide (Irbesartan/ Hydrochlorothiazide)?
You can order Avalide (Irbesartan/ Hydrochlorothiazide) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
Please call 1-800-258-0477 or email us if you have any questions or concerns.
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