Septra (Sulfamethoxazole/Trimethoprim)

Sulfamethoxazole, Trimethoprim

Septra Injection
Sulfamethoxazole, Trimethoprim

Septra Injection
Sulfamethoxazole, Trimethoprim


Generic Equivalents   What's the difference?
Sulfamethoxazole, Trimethoprim



Septra (Sulfamethoxazole/Trimethoprim)

Septra (Sulfamethoxazole/Trimethoprim)

Septra is a potent antibiotic combination that includes sulfamethoxazole and trimethoprim. It works by inhibiting the growth of bacteria, making it an effective treatment for a variety of bacterial infections. This includes urinary tract infections, bronchitis, otitis media (middle ear infections), travelers’ diarrhea, and Pneumocystis carinii pneumonia (PCP) among others.

Why Choose Septra (Sulfamethoxazole/Trimethoprim)?

  • Broad-Spectrum Antibiotic: Effective against a wide range of bacterial infections.
  • Fast-Acting: Starts working quickly to reduce symptoms and fight the infection.
  • Convenient Dosing: Available in both tablet and liquid form to suit individual needs and preferences.

How to Use Septra (Sulfamethoxazole/Trimethoprim)?

  • Prescription Required: Septra should only be used under the guidance of a healthcare provider.
  • Dosage: Follow your doctor’s instructions regarding dosage and duration of treatment.Do not adjust your dose without consulting your healthcare provider.
  • Administration: This can be taken with or without food. If stomach upset occurs, taking it with food or milk may help.

Important Safety Information about Septra

  • Always take Septra exactly as prescribed by your healthcare provider.
  • Be sure to discuss your full medical history with your doctor, especially if you have liver or kidney disease, a folate (folic acid) deficiency, a history of alcohol abuse, or if you have HIV or AIDS.
  • Inform your doctor about all medications you are taking, as Septra can interact with other drugs.
  • Avoid prolonged exposure to sunlight or tanning beds, as Septra can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
  • Stay hydrated by drinking plenty of fluids while taking Septra to help prevent kidney stones.

Fact Table for Septra

Brand Name(s) Septra, Bactrim
Generic Name

Drug Class Antibiotic (Sulfonamide)

FDA Approval Yes

Indications Urinary tract infections, acute otitis media, bronchitis, traveler’s diarrhea, Pneumocystis jiroveci pneumonia, and certain types of gastroenteritis


Known hypersensitivity to sulfonamides or trimethoprim, significant renal or hepatic impairment, pregnant patients at term, nursing mothers, infants under 2 months of age

Common Side Effects

Nausea, vomiting, rash, dizziness, headache, photosensitivity

Serious Side Effects

Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, hyperkalemia, hepatic necrosis, severe hypersensitivity reactions

Dosing Information

Varies by indication and patient age/weight. Typically, for adults, the standard dose is one tablet (400 mg sulfamethoxazole/80 mg trimethoprim) every 12 hours for 10 to 14 days for UTIs.


Oral (tablet or liquid)

Special Considerations

Drink plenty of fluids to prevent kidney stones. Monitor for signs of blood disorders (e.g., sore throat, fever, pallor). Avoid during pregnancy, especially near term. Be cautious in patients with G6PD deficiency due to the risk of hemolysis. Monitor renal and hepatic functions during long-term use.
Drug Interactions

Warfarin (increased risk of bleeding), methotrexate (increased toxicity), ACE inhibitors (risk of hyperkalemia), diuretics (enhanced nephrotoxicity)

Mechanism of Action

Inhibits sequential steps in bacterial folic acid synthesis, making it bactericidal against susceptible organisms

Common Side Effects of Septra

Like all medications, Septra (Sulfamethoxazole/Trimethoprim) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Nausea or vomiting
  • Loss of appetite
  • Diarrhea
  • Dizziness or headache
  • Mild rash or itching

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Septra (Sulfamethoxazole/Trimethoprim)?

You can order Septra (Sulfamethoxazole/Trimethoprim) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills
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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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Please note that due to government rules and regulations, orders may not exceed 3 months in supply.
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