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Premarin is a prescription medication containing conjugated estrogens, which are a mixture of estrogen hormones. It is commonly used as a hormone replacement therapy (HRT) for women experiencing menopausal symptoms.
Why Choose Premarin?
Relief from menopausal symptoms
Prevention of osteoporosis in postmenopausal women
Improves vaginal health and reduces dryness
Can be used to treat certain hormone-related conditions
How to use Premarin?
Premarin is available in tablet form and is typically taken once daily, with or without food. The dosage may vary depending on the individual’s medical condition and response to therapy. Your healthcare provider will determine the appropriate dose for you. It is important to take Premarin as prescribed and to follow your healthcare provider’s instructions regarding any necessary adjustments to your dose or treatment plan.
Important Safety Information Premarin
Before starting Premarin, inform your healthcare provider of your medical history, especially if you have a history of blood clots, liver disease, stroke, heart disease, or certain types of cancer. Premarin may also interact with other medications, so it is important to inform your healthcare provider of any other medications you are taking.
Premarin should not be used during pregnancy, as it may harm the unborn baby. If you become pregnant while taking Premarin, discontinue use and contact your healthcare provider. It is also not recommended for use while breastfeeding, as it may pass into breast milk and affect the nursing infant.
Fact Table for Premarin
Fact Category
Fact Details
Brand Name
Premarin
Generic Name
Conjugated Estrogens
Drug Class
Hormone Replacement Therapy (HRT)
Uses
Menopausal symptom relief, prevention of osteoporosis, vaginal health improvement
Interactions
May interact with many other medications; inform the healthcare provider of all medications being taken
Administration
Oral tablets, taken once daily with or without food
Pregnancy and Breastfeeding
Not recommended during pregnancy or breastfeeding
Monitoring and Follow-up
Regular follow-ups with the healthcare provider to monitor progress and adjust dosage as needed
Common Side Effects of Premarin
As with any medication, Premarin may cause side effects. Some common side effects include:
Nausea
Vomiting
Breast tenderness
Headache
Swelling of hands, feet, or ankles
Serious side effects may also occur, such as blood clots, strokes, or heart attacks. If you experience any severe or persistent side effects, contact your healthcare provider immediately.
How Can You Buy Premarin (Estrogens, Conjugated)?
You can order Premarin (Estrogens, Conjugated)using these methods on our website:
Premarin tablets contain a combination of estrogen hormones called conjugated estrogens. These hormones are naturally produced by the ovaries and play a crucial role in various physiological processes within the body.
Premarin is composed of conjugated estrogens, with a portion sourced from the urine of pregnant horses. Although it doesn’t contain any animal meat or tissue, individuals adhering to vegan or vegetarian lifestyles might opt for alternative hormone replacement therapy (HRT) options like Elleste Solo or Evorel which do not involve equine-derived ingredients.
Premarin is prescribed post-menopause to address specific health concerns, including: Hot Flash Relief: Post-menopausal women often experience moderate to severe hot flashes, triggered by the decrease in naturally produced estrogen. Premarin can effectively alleviate these uncomfortable symptoms, which include sudden warmth, heat sensations, and sweating.
Vaginal Menopausal Changes: For those encountering discomfort and changes in and around the vaginal area during menopause, Premarin can provide relief. It’s essential to consult your healthcare provider about the necessity of this treatment or explore topical vaginal alternatives. Osteoporosis Prevention: Post-menopausal osteoporosis, characterized by brittle bones, is another concern addressed by Premarin. It may be recommended to reduce the risk of osteoporosis, but your healthcare provider can help determine if non-estrogen treatments, weight-bearing exercises, calcium, and vitamin D supplements are more suitable. Other Uses: Premarin may also be used to treat pre-menopausal women with insufficient natural estrogen production and to alleviate symptoms in individuals with certain cancers that have metastasized in both men and women.
Do not take Premarin if you have unusual vaginal bleeding, certain cancers (especially breast or uterine cancer), a history of stroke or heart attack, a current or previous history of blood clots, liver problems, a diagnosed bleeding disorder, known allergy to Premarin or its components, or if you suspect pregnancy. These conditions may pose risks or contraindications to using Premarin. Always consult with your healthcare provider for guidance on appropriate treatment options.
Unusual Vaginal Bleeding
If you experience any abnormal vaginal bleeding, especially after menopause, it could be a potential sign of uterine (womb) cancer. Your healthcare provider should investigate the cause of this bleeding.
Medical Conditions
Disclose all your medical conditions, such as asthma, epilepsy, diabetes, migraines, endometriosis, lupus, heart issues, liver problems, thyroid disorders, kidney concerns, or high calcium levels in your blood. Your healthcare provider may need to monitor you more closely due to these conditions.
Medications
Share a comprehensive list of all medications you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Some medications may interact with Premarin, affecting its effectiveness or how other medicines work.
Upcoming Surgery or Bed rest
If you have surgery planned or anticipate being on bed rest, your healthcare provider may advise temporarily discontinuing Premarin.
Breastfeeding
If you are breastfeeding, be aware that the hormones in Premarin can pass into your breast milk, and this should be discussed with your healthcare provider.
Premarin may have varying side effects classified by severity and occurrence.
Serious but rare side effects are heart attack, stroke, blood clots, dementia, breast cancer, uterine and ovarian cancer, high blood pressure, increased blood sugar, gallbladder disease, liver problems, enlargement of uterine tumors (fibroids), and severe allergic reactions. You should immediately consult your healthcare provider if you observe warning signs such as new breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden severe headaches, or chest/leg pains with or without shortness of breath
Less severe and common side effects include headaches, breast pain, irregular vaginal bleeding, abdominal cramps, nausea, vomiting, hair loss, fluid retention, and vaginal yeast infections.
Premarin consists of conjugated estrogens, specifically a combination of sodium estrone sulfate and sodium equilin sulfate. Additionally, it contains other elements like sodium sulfate conjugates, 17 α-dihydroequilin, 17 α-estradiol, and 17 β-dihydroequilin.
There are some inactive ingredients present in it like calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose and titanium dioxide.
A decrease in estrogen levels can lead to a decline in libido for some women. Menopausal symptoms vary, but using supplements with estrogen may help increase sexual drive.
If a dose is missed, take it immediately. If your next dose is approaching, skip the missed one and resume your regular schedule. Avoid taking two doses simultaneously.
In case of Premarin overdose, even if there are no symptoms of poisoning or discomfort, you should immediately consult your doctor or seek emergency medical help.
Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care. View Linkedin profile
Please note that due to government rules and regulations, orders may not exceed 3 months in supply. Please call 1-800-258-0477 or email us if you have any questions or concerns.
What is generic medication?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, how it is taken, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name and works the same way in the body in the same amount of time.
The only differences between generics and their brand-name counterparts is the generics are less expensive and may look slightly different (e.g. different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to invent a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name drug and sell it at substantial discounts.
