Premarin (Estrogens, Conjugated)

Product Review

Estrogens, Conjugated

Conjugated Estrogens


Premarin (Estrogens, Conjugated)

Premarin (Estrogens, Conjugated)

Premarin is a prescription medication containing conjugated estrogens, which are a mixture of estrogen hormones. It is commonly used as a hormone replacement therapy (HRT) for women experiencing menopausal symptoms.

Why Choose Premarin?

  • Relief from menopausal symptoms
  • Prevention of osteoporosis in postmenopausal women
  • Improves vaginal health and reduces dryness
  • Can be used to treat certain hormone-related conditions

How to use Premarin?

Premarin is available in tablet form and is typically taken once daily, with or without food. The dosage may vary depending on the individual’s medical condition and response to therapy. Your healthcare provider will determine the appropriate dose for you. It is important to take Premarin as prescribed and to follow your healthcare provider’s instructions regarding any necessary adjustments to your dose or treatment plan.

Important Safety Information Premarin

Before starting Premarin, inform your healthcare provider of your medical history, especially if you have a history of blood clots, liver disease, stroke, heart disease, or certain types of cancer. Premarin may also interact with other medications, so it is important to inform your healthcare provider of any other medications you are taking.

Premarin should not be used during pregnancy, as it may harm the unborn baby. If you become pregnant while taking Premarin, discontinue use and contact your healthcare provider. It is also not recommended for use while breastfeeding, as it may pass into breast milk and affect the nursing infant.

Fact Table for Premarin

Fact Category Fact Details
Brand Name Premarin
Generic Name Conjugated Estrogens
Drug Class Hormone Replacement Therapy (HRT)
Uses Menopausal symptom relief, prevention of osteoporosis, vaginal health improvement
Interactions May interact with many other medications; inform the healthcare provider of all medications being taken
Administration Oral tablets, taken once daily with or without food
Pregnancy and Breastfeeding Not recommended during pregnancy or breastfeeding
Monitoring and Follow-up Regular follow-ups with the healthcare provider to monitor progress and adjust dosage as needed

Common Side Effects of Premarin

As with any medication, Premarin may cause side effects. Some common side effects include:

  • Nausea
  • Vomiting
  • Breast tenderness
  • Headache
  • Swelling of hands, feet, or ankles

Serious side effects may also occur, such as blood clots, strokes, or heart attacks. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

How Can You Buy Premarin (Estrogens, Conjugated)?

You can order Premarin (Estrogens, Conjugated)using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. References

    Premarin [Package Insert].Philadelphia, PA: Pfizer;2018

  2. What are the available strengths of Premarin?

    Each Premarin tablet comes in different strengths, distinguished by color and ingredient

    • 0.3 mg tablet (green): D&C Yellow No. 10 and FD&C Blue No. 2.
    • 0.45 mg tablet (blue): FD&C Blue No. 2.
    • 0.625 mg tablet (maroon): FD&C Blue No. 2 and FD&C Red No. 40.
    • 0.9 mg tablet (white): D&C Red No. 30 and D&C Red No. 7.
    • 1.25 mg tablet (yellow): Black iron oxide, D&C Yellow No. 10, and FD&C Yellow No. 6.
  3. What should I do if I overdose on Premarin?

    In case of Premarin overdose, even if there are no symptoms of poisoning or discomfort, you should immediately consult your doctor or seek emergency medical help.

  4. Is it necessary to take Premarin with food?

    It is not necessary to take Premarin with food. It is your choice whether you want to consume it with food or not.

  5. How long should I consume Premarin?

    Use estrogen as you need for treatment and only for as long as necessary. Consult your doctor regularly and act as per his instructions.

  6. What to do if I miss a dose of Premarin?

    If a dose is missed, take it immediately. If your next dose is approaching, skip the missed one and resume your regular schedule. Avoid taking two doses simultaneously.

  7. What is the ideal time to take Premarin?

    You can take Premarin at any time which is convenient for you. However, it will be more effective to fix any specific time in a day to take Premarin.

  8. Does Premarin affect libido?

    A decrease in estrogen levels can lead to a decline in libido for some women. Menopausal symptoms vary, but using supplements with estrogen may help increase sexual drive.

  9. What is the Ideal temperature to store Premarin?

    The ideal temperature ranges between 20°C to 25°C (68° – 77°F).

  10. What is Premarin made of?

    Premarin consists of conjugated estrogens, specifically a combination of sodium estrone sulfate and sodium equilin sulfate. Additionally, it contains other elements like sodium sulfate conjugates, 17 α-dihydroequilin, 17 α-estradiol, and 17 β-dihydroequilin.
    There are some inactive ingredients present in it like calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose and titanium dioxide.

  11. What are the side effects of Premarin?

    Premarin may have varying side effects classified by severity and occurrence.
    Serious but rare side effects are heart attack, stroke, blood clots, dementia, breast cancer, uterine and ovarian cancer, high blood pressure, increased blood sugar, gallbladder disease, liver problems, enlargement of uterine tumors (fibroids), and severe allergic reactions. You should immediately consult your healthcare provider if you observe warning signs such as new breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden severe headaches, or chest/leg pains with or without shortness of breath

    Less severe and common side effects include headaches, breast pain, irregular vaginal bleeding, abdominal cramps, nausea, vomiting, hair loss, fluid retention, and vaginal yeast infections.

  12. What crucial information do I need to provide my doctor before starting Premarin?

    Inform your healthcare provider:

    Unusual Vaginal Bleeding
    If you experience any abnormal vaginal bleeding, especially after menopause, it could be a potential sign of uterine (womb) cancer. Your healthcare provider should investigate the cause of this bleeding.

    Medical Conditions
    Disclose all your medical conditions, such as asthma, epilepsy, diabetes, migraines, endometriosis, lupus, heart issues, liver problems, thyroid disorders, kidney concerns, or high calcium levels in your blood. Your healthcare provider may need to monitor you more closely due to these conditions.

    Share a comprehensive list of all medications you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Some medications may interact with Premarin, affecting its effectiveness or how other medicines work.

    Upcoming Surgery or Bed rest
    If you have surgery planned or anticipate being on bed rest, your healthcare provider may advise temporarily discontinuing Premarin.

    If you are breastfeeding, be aware that the hormones in Premarin can pass into your breast milk, and this should be discussed with your healthcare provider.

  13. Who should avoid Premarin?

    Do not take Premarin if you have unusual vaginal bleeding, certain cancers (especially breast or uterine cancer), a history of stroke or heart attack, a current or previous history of blood clots, liver problems, a diagnosed bleeding disorder, known allergy to Premarin or its components, or if you suspect pregnancy. These conditions may pose risks or contraindications to using Premarin. Always consult with your healthcare provider for guidance on appropriate treatment options.

  14. What are the uses of Premarin?

    Premarin is prescribed post-menopause to address specific health concerns, including:
    Hot Flash Relief: Post-menopausal women often experience moderate to severe hot flashes, triggered by the decrease in naturally produced estrogen. Premarin can effectively alleviate these uncomfortable symptoms, which include sudden warmth, heat sensations, and sweating.
    Vaginal Menopausal Changes: For those encountering discomfort and changes in and around the vaginal area during menopause, Premarin can provide relief. It’s essential to consult your healthcare provider about the necessity of this treatment or explore topical vaginal alternatives.
    Osteoporosis Prevention: Post-menopausal osteoporosis, characterized by brittle bones, is another concern addressed by Premarin. It may be recommended to reduce the risk of osteoporosis, but your healthcare provider can help determine if non-estrogen treatments, weight-bearing exercises, calcium, and vitamin D supplements are more suitable.
    Other Uses: Premarin may also be used to treat pre-menopausal women with insufficient natural estrogen production and to alleviate symptoms in individuals with certain cancers that have metastasized in both men and women.

  15. Can vegans consume Permarin?

    Premarin is composed of conjugated estrogens, with a portion sourced from the urine of pregnant horses. Although it doesn’t contain any animal meat or tissue, individuals adhering to vegan or vegetarian lifestyles might opt for alternative hormone replacement therapy (HRT) options like Elleste Solo or Evorel which do not involve equine-derived ingredients.

  16. Can you provide information about Premarin?

    Premarin tablets contain a combination of estrogen hormones called conjugated estrogens. These hormones are naturally produced by the ovaries and play a crucial role in various physiological processes within the body.

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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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