Frequently Asked Questions

1. References

   Linzess [package insert]. Cambridge, MA: Allergan; 2017.

2. Is Linzess a laxative?

   Linzess is not a laxative; instead, it acts as a stool softener. It works by increasing water and chloride secretion in the intestines, which helps soften stools and stimulate bowel movements. Unlike traditional laxatives, Linzess is typically taken once daily and may take about a week to provide constipation relief, depending on the individual’s medical condition.

3. Does Linzess help in weight loss?

   Linzess is not intended or prescribed as a weight loss medication. Nonetheless, some individuals who have been using Linzess to manage chronic constipation have reported weight loss as an unintended side effect. This weight loss is primarily attributed to the medication’s side effect of diarrhea, which can lead to a significant loss of electrolytes and water from the body among certain patients.

4. How much time does Linzess take to show its results?

   Linzess, not being a rapid-acting laxative, typically requires some time to show its therapeutic effects. In most cases, individuals may start to observe changes in their constipation symptoms after using the medication consistently for at least one week. However, for patients dealing with irritable bowel syndrome (IBS) accompanied by constipation, significant improvements are usually noticeable only after consistently taking the medication for 12 weeks.

5. Is it safe to take Linzess alongside other medications?

   Linzess can generally be taken concurrently with other medications without significant interactions or safety concerns. However, it’s important to avoid specific laxatives like magnesium citrate, sodium phosphate, and polyethylene glycol while using Linzess, as they may heighten the risk of experiencing diarrhea. For a more comprehensive understanding of Linzess, including its potential side effects, appropriate dosage, precautions, and indications, it is advisable to consult your doctor.

6. What are the key points to remember about Linzess?

   Linzess should not be administered to children under 18 years of age as it may be harmful to them.

7. Is there a specific time of day when I should take Linzess?

   Yes, it’s recommended to take Linzess 30 minutes before your first meal of the day, ensuring that you do so on an empty stomach.

8. What should I do if I find it difficult to swallow the capsule?

   If you are having trouble swallowing the capsule, you can open it and mix the contents with either a teaspoon of applesauce or 30 milliliters of water. It is advised not to crush or chew the capsules.

9. List the ingredients of Linzess.

   Linzess contains linaclotide as its active ingredient. The inactive ingredients vary depending on the dosage strength of the capsules:

   For 145 mcg and 290 mcg capsules, the inactive ingredients include calcium chloride dihydrate, hypromellose, L-leucine, and microcrystalline cellulose. Gelatin and titanium dioxide are used to make the capsule shell.

   For 72 mcg capsules, the inactive ingredients consist of calcium chloride dihydrate, L-histidine, microcrystalline cellulose, polyvinyl alcohol, and talc. The capsule shell is also composed of gelatin and titanium dioxide.

10. How to store Linzess?

    To properly store Linzess, follow these guidelines:

    • Keep Linzess at a room temperature range of 68°F to 77°F (20°C to 25°C).
    • Keep Linzess in its original bottle.
    • Inside the Linzess bottle, you’ll find a desiccant packet designed to prevent moisture damage. Do not remove this desiccant packet.
    • Ensure the Linzess bottle is tightly sealed and stored in a dry location.
    • Keep Linzess and all medications out of the reach of children.
11. What are the side effects of Linzess?

    Linzess may lead to several side effects, including the following:

    • The most common side effect is diarrhea, which can occasionally become severe and usually starts within the first two weeks of treatment with Linzess. If you experience severe diarrhea while taking Linzess, discontinue the medication and contact your doctor immediately.
    • Other common side effects of Linzess encompass gas, abdominal pain, and a sensation of fullness or pressure in the abdomen (distention).
    • If you encounter unusual or severe abdominal pain, particularly if accompanied by bright red, bloody stools or black tar-like stools, seek immediate medical attention by contacting your doctor or visiting the nearest hospital emergency room.

    It is important to note that these are not the only potential side effects of Linzess. For additional information regarding side effects, consult your doctor for medical advice.

12. What if a dose of Linzess is missed?

    If a dose of Linzess is missed, skip it and proceed to take your next scheduled dose at the usual time. It is advised not to take two doses at the same time.

13. How to take Linzess?

    Linzess is an oral medication meant to be ingested by mouth. The entire capsule should be swallowed whole without chewing or breaking it. It is advisable to take this medication in the morning on an empty stomach. For optimal results, Linzess is typically prescribed to be taken 30 minutes before your first meal of the day.

14. What should you discuss with your doctor before starting Linzess medication?

    Before initiating Linzess, it is crucial to have a thorough discussion with your doctor regarding your medical history and other factors. Here are the key points:

    • Medical Conditions: Inform your doctor about any existing medical conditions you may have.
    • Pregnancy: If you are currently pregnant or planning to become pregnant, it’s essential to discuss this with your doctor. The effects of Linzess on unborn babies are not fully known.
    • Breastfeeding: If you are currently breastfeeding or planning to breastfeed, talk to your doctor about the potential transfer of Linzess into breast milk and the best feeding approach for your baby.
    • Medications: Make sure to provide your doctor with a comprehensive list of all the medications you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. This information will help your doctor assess any potential interactions or concerns related to Linzess.
15. Is it advisable to take Linzess (linaclotide) in the evening?

    Taking Linzess in the evening is not recommended. It is best to take Linzess in the morning, about 30 minutes before having breakfast, on an empty stomach.

16. Who should avoid taking Linzess?

    Do not administer Linzess to children under 6 years old, as it may lead to severe diarrhea and potential dehydration due to excessive loss of body water and salt. Additionally, individuals with a diagnosed bowel blockage (intestinal obstruction) should refrain from taking Linzess.

17. What is Linzess?

    Linzess is a prescription medication prescribed for adults to manage two conditions:

    • Irritable bowel syndrome with constipation (IBS-C).
    • Chronic idiopathic constipation (CIC), where the cause of constipation is unknown.

    It’s important to note that the safety and effectiveness of Linzess in individuals under 18 years of age have not been established.