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Linzess (linaclotide) is a prescription medication designed to treat patients suffering from irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). Linzess works by increasing the secretion of chloride and water in the intestines, which helps to soften the stool and stimulate bowel movements. With Linzess, you can experience relief from constipation and abdominal pain, improving your overall quality of life.
Why Choose Linzess (Linaclotide)?
Linzess is a guanylate cyclase-C (GC-C) agonist that works locally in the intestines. By increasing the concentration of chloride and water in the intestines, Linzess softens the stool and promotes bowel movements, providing relief from constipation. Additionally, Linzess has been shown to help reduce abdominal pain by decreasing the activity of pain-sensing nerves in the intestines.
Effective relief from the symptoms of IBS-C and CIC
Softens stools and promotes regular bowel movements
Reduces abdominal pain and discomfort
How to use Linzess (Linaclotide)?
Linzess is available in capsule form and should be taken once daily, typically 30 minutes before the first meal of the day. It is important to follow your healthcare provider’s instructions regarding the correct dosage and administration of Linzess. Do not crush, chew, or break the capsule; swallow it whole with a glass of water.
Important Safety Information Linzess
Before starting Linzess, inform your healthcare provider about any medical conditions or allergies you have, as well as all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Linzess should not be used by patients under 18 years of age.
Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Linzess during pregnancy and lactation has not been established.
Fact Table
Generic Name
Linaclotide
Brand Name
Linzess
Drug class
Guanylate cyclase-C (GC-C) agonist
FDA approval
August 2012
Indications
Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC)
Mechanism of action
Increases secretion of chloride and water in the intestines softens stool, stimulates bowel movements, and decreases pain-sensing nerve activity
Dosage forms
Capsule
Dosage instructions
Once daily, typically 30 minutes before the first meal of the day
Contraindications
Patients under 18 years of age
Storage
Store at room temperature, away from heat, moisture, and direct light
Common Side Effects
Like all medications, Linzess (Linaclotide) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
Diarrhea
Dehydration
Dizziness
Lightheadedness
Decrease in urine output
If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Linzess (Linaclotide)?
You can order Linzess (Linaclotide) using these methods on our website:
Do not administer Linzess to children under 6 years old, as it may lead to severe diarrhea and potential dehydration due to excessive loss of body water and salt. Additionally, individuals with a diagnosed bowel blockage (intestinal obstruction) should refrain from taking Linzess.
Taking Linzess in the evening is not recommended. It is best to take Linzess in the morning, about 30 minutes before having breakfast, on an empty stomach.
Before initiating Linzess, it is crucial to have a thorough discussion with your doctor regarding your medical history and other factors. Here are the key points:
Medical Conditions: Inform your doctor about any existing medical conditions you may have.
Pregnancy: If you are currently pregnant or planning to become pregnant, it’s essential to discuss this with your doctor. The effects of Linzess on unborn babies are not fully known.
Breastfeeding: If you are currently breastfeeding or planning to breastfeed, talk to your doctor about the potential transfer of Linzess into breast milk and the best feeding approach for your baby.
Medications: Make sure to provide your doctor with a comprehensive list of all the medications you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. This information will help your doctor assess any potential interactions or concerns related to Linzess.
Linzess is an oral medication meant to be ingested by mouth. The entire capsule should be swallowed whole without chewing or breaking it. It is advisable to take this medication in the morning on an empty stomach. For optimal results, Linzess is typically prescribed to be taken 30 minutes before your first meal of the day.
If a dose of Linzess is missed, skip it and proceed to take your next scheduled dose at the usual time. It is advised not to take two doses at the same time.
Linzess may lead to several side effects, including the following:
The most common side effect is diarrhea, which can occasionally become severe and usually starts within the first two weeks of treatment with Linzess. If you experience severe diarrhea while taking Linzess, discontinue the medication and contact your doctor immediately.
Other common side effects of Linzess encompass gas, abdominal pain, and a sensation of fullness or pressure in the abdomen (distention).
If you encounter unusual or severe abdominal pain, particularly if accompanied by bright red, bloody stools or black tar-like stools, seek immediate medical attention by contacting your doctor or visiting the nearest hospital emergency room.
It is important to note that these are not the only potential side effects of Linzess. For additional information regarding side effects, consult your doctor for medical advice.
Linzess contains linaclotide as its active ingredient. The inactive ingredients vary depending on the dosage strength of the capsules:
For 145 mcg and 290 mcg capsules, the inactive ingredients include calcium chloride dihydrate, hypromellose, L-leucine, and microcrystalline cellulose. Gelatin and titanium dioxide are used to make the capsule shell.
For 72 mcg capsules, the inactive ingredients consist of calcium chloride dihydrate, L-histidine, microcrystalline cellulose, polyvinyl alcohol, and talc. The capsule shell is also composed of gelatin and titanium dioxide.
If you are having trouble swallowing the capsule, you can open it and mix the contents with either a teaspoon of applesauce or 30 milliliters of water. It is advised not to crush or chew the capsules.
Linzess can generally be taken concurrently with other medications without significant interactions or safety concerns. However, it’s important to avoid specific laxatives like magnesium citrate, sodium phosphate, and polyethylene glycol while using Linzess, as they may heighten the risk of experiencing diarrhea. For a more comprehensive understanding of Linzess, including its potential side effects, appropriate dosage, precautions, and indications, it is advisable to consult your doctor.
Linzess, not being a rapid-acting laxative, typically requires some time to show its therapeutic effects. In most cases, individuals may start to observe changes in their constipation symptoms after using the medication consistently for at least one week. However, for patients dealing with irritable bowel syndrome (IBS) accompanied by constipation, significant improvements are usually noticeable only after consistently taking the medication for 12 weeks.
Linzess is not intended or prescribed as a weight loss medication. Nonetheless, some individuals who have been using Linzess to manage chronic constipation have reported weight loss as an unintended side effect. This weight loss is primarily attributed to the medication’s side effect of diarrhea, which can lead to a significant loss of electrolytes and water from the body among certain patients.
Linzess is not a laxative; instead, it acts as a stool softener. It works by increasing water and chloride secretion in the intestines, which helps soften stools and stimulate bowel movements. Unlike traditional laxatives, Linzess is typically taken once daily and may take about a week to provide constipation relief, depending on the individual’s medical condition.
Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care.
He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff.
He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications.
His clinical specialties include: anticoagulation, diabetes management, and psychiatric care. View Linkedin profile
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What is generic medication?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, how it is taken, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name and works the same way in the body in the same amount of time.
The only differences between generics and their brand-name counterparts is the generics are less expensive and may look slightly different (e.g. different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to invent a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name drug and sell it at substantial discounts.
