Januvia (Sitagliptin)

Sitagliptin Phosphate

Sitagliptin Phosphate


Januvia (Sitagliptin)

Januvia, also known by its active ingredient Sitagliptin, is an innovative oral medication designed for the management of type 2 diabetes. As part of a comprehensive treatment plan that includes diet and exercise, Januvia works by regulating the levels of insulin your body produces after eating. This medication is tailored for adults with type 2 diabetes to improve blood sugar control and provide a pivotal component in the management of diabetes.

Why Choose Januvia (Sitagliptin)?

  • Enhances Blood Sugar Control:Januvia effectively lowers blood sugar levels by enhancing the body’s natural ability to control high blood sugar.This leads to improved A1C levels, a critical factor in the long-term management of type 2 diabetes.
  • Once-Daily Convenience:With its once-daily dosing, Januvia offers a convenient option for diabetes management, fitting seamlessly into daily routines.
  • Works with Your Body:Sitagliptin works by increasing substances in the body that lower blood sugar when it is high. It does this by enhancing the function of pancreatic cells that produce insulin and reducing the liver’s sugar production.
  • Low Risk of Hypoglycemia:When used alone, Januvia has a low risk of causing hypoglycemia (low blood sugar levels) compared to other diabetes medications, making it a safer option for many patients..

How to Use Januvia (Sitagliptin)?

  • Dosage Frequency:Take Januvia once daily.
  • Food Instructions:This can be taken with or without food.
  • Dosage Determination:Dosage is based on medical condition, kidney function, and response to treatment.
  • Follow Prescription:Always take Januvia as prescribed by your healthcare professional.
  • Consistency Is Key:Maintain a consistent daily routine for taking Januvia to ensure steady blood sugar levels.
  • Consultation Requirement:Do not change your dose or stop taking Januvia without consulting your doctor.

Important Safety Information about Januvia

  • Medical History:Before starting Januvia, inform your doctor about your medical history, especially if you have kidney disease, pancreatitis, stones in your gallbladder (gallstones), or a history of alcoholism.
  • Monitoring:
    Regular monitoring of blood sugar levels and kidney function is important while taking Januvia. Your healthcare provider will guide you on how often these tests are needed.
  • Pregnancy and Breastfeeding:Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding,
    as it is unclear how Januvia may affect these conditions.
  • Drug Interactions:Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Januvia may affect how other medicines work and other medicines may affect how Januvia works.

Fact Table for Januvia

Generic Name Sitagliptin
Brand Name Januvia
Drug Class Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
FDA Approval Year 2006
Indications Used to improve glycemic control in adults with type 2 diabetes mellitus
Dosage Forms Tablets (25 mg, 50 mg, 100 mg)
Administration Route Oral
Recommended Dosage 100 mg once daily, can be adjusted based on renal function
Mechanism of Action Inhibits the DPP-4 enzyme, which increases
levels of incretin hormones, improving insulin release and
decreasing glucagon levels in the blood.
Key Side Effects Upper respiratory tract infection,
nasopharyngitis, headache, hypoglycemia (when used with other diabetes medications),
and stomach pain
Interactions May interact with digoxin and other medications affecting kidney function or glucose metabolism
Precautions Not for treatment of type 1 diabetes or
diabetic ketoacidosis. Use caution in patients with a history of pancreatitis.
Pregnancy Category B (No evidence of risk in humans, but studies are limited)
Lactation Unknown if excreted in human milk; use caution
Renal Dosing Adjustment Required for patients with renal impairment;
dosage adjustments based on the degree of renal dysfunction

Common Side Effects of Januvia

Like all medications, Januvia (Sitagliptin) can cause side effects, although not everybody gets them.
Understanding these side effects can help you use this medication safely and effectively.

  • Nasopharyngitis (common cold)
  • Headache
  • Upper respiratory tract infectio
  • Stuffy or runny nose and sore throat
  • Hypoglycemia

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Januvia (Sitagliptin)?

You can order Januvia using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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Please note that due to government rules and regulations, orders may not exceed 3 months in supply.
Please call 1-800-258-0477 or email us if you have any questions or concerns.