Enbrel (Etanercept)

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Enbrel SURECLICK injection
Etanercept

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Enbrel (Etanercept)

Enbrel (Etanercept)

Enbrel® (Etanercept) is a biologic medication approved for the treatment of several chronic inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Enbrel works by targeting and inhibiting the tumor necrosis factor (TNF), a protein in the body that contributes to inflammation and immune system responses.

Why Choose Enbrel (Etanercept)?

  • Reduces Inflammation: Helps decrease the level of systemic inflammation, providing relief from pain and swelling.
  • Slows Disease Progression: May prevent further joint damage in rheumatoid arthritis and other diseases.
  • Improves Physical Function: Enhances quality of life by improving mobility and decreasing pain.
  • Treats Skin Conditions: Effective in reducing the symptoms and appearance of moderate to severe plaque psoriasis.

How to Use Enbrel (Etanercept)?

  • Rotate injection sites: Common injection sites include the thighs, abdomen, and upper arms. Avoid areas where the skin is tender, bruised, red, or hard.
  • Clean the injection site: Use an alcohol swab to clean the skin where the injection will be administered. Allow the area to air dry.
  • Remove cap: Take off the cap from the syringe or autoinjector, taking care not to touch the needle.
  • Inject the medication: For a syringe, pinch the skin lightly and insert the needle at about a 45-degree angle. For an autoinjector, place it flat against the skin and press down until it triggers.
  • Press the plunger: If using a syringe, gently push the plunger down. Hold the autoinjector in place until all medication is injected.
  • Withdraw needle: Remove the needle or autoinjector and apply light pressure to the site with a gauze pad if necessary. Do not rub the injection site.
  • Dispose of properly: Place used needles, syringes, and autoinjectors in an FDA-approved sharps disposal container immediately after use. Do not throw them in the trash.

Important Safety Information about Enbrel

  • Check the label: Ensure the medication has not expired and it is the correct dose as prescribed by your doctor.
  • Inspect the solution: Enbrel should be clear and colorless to slightly yellow. Do not use it if the solution is cloudy, discolored, or has particles in it.
  • Allow it to reach room temperature: If stored in the refrigerator, allow the prefilled syringe or autoinjector to sit at room temperature for about 15 to 30 minutes before use. Do not warm it in any other way (e.g., do not warm it in a microwave or hot water).
  • Allergic Reactions: Some patients have had severe allergic reactions to the active or inactive components of Enbrel. Immediate medical attention is required if symptoms of a serious allergic reaction occur.
  • Vaccinations: Discuss with your healthcare provider before receiving any vaccines. Certain vaccines may not be advisable.

Fact Table for Enbrel

Facts Details
Generic Name Etanercept
Brand Names Enbrel
Drug Class Tumor Necrosis Factor (TNF) inhibitor
FDA Approval Initially approved in 1998
Indications – Rheumatoid Arthritis – Psoriatic Arthritis – Ankylosing Spondylitis – Plaque Psoriasis – Juvenile Idiopathic Arthritis
Administration Subcutaneous injection
Dosage Forms – Pre-filled syringe – Auto-injector pen
Typical Dosage 50 mg once weekly for adults (may vary based on condition and patient response)
How It Works Inhibits the activity of tumor necrosis factor-alpha (TNF-alpha), a substance in the body that causes inflammation and immune system activity
Major Benefits – Reduces symptoms of inflammation – Slows progression of joint damage – Improves physical function
Common Side Effects – Injection site reactions (redness, itching, swelling) – Upper respiratory infections – Headaches
Contraindications – History of serious infections – History of hypersensitivity to etanercept or its components
Monitoring Regular monitoring for signs of infection, changes in blood counts, and new or worsening heart failure
Pregnancy Category Category B (no evidence of risk in humans, but should still be used under medical advice)
Interactions – Live vaccines – Other immunosuppressive agents
Storage Requirements Store in a refrigerator (2°C to 8°C/36°F to 46°F), protect from light, do not freeze

Common Side Effects of Enbrel

Like all medications, Enbrel (Etanercept) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Injection site reactions
  • Upper respiratory infections
  • Headaches

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Enbrel (Etanercept)?

You can order Enbrel (Etanercept) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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