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Daraprim (Pyrimethamine)

Daraprim
Pyrimethamine
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Daraprim (Pyrimethamine)

Daraprim (Pyrimethamine)

Daraprim (Pyrimethamine) is a prescription medication that plays a crucial role in the treatment of parasitic diseases, including toxoplasmosis and malaria. This medication is specifically designed for individuals who are particularly vulnerable to these infections, including pregnant women and individuals with weakened immune systems.

Why Choose Daraprim (Pyrimethamine)?

  • Active Ingredient: Contains Pyrimethamine as the active pharmaceutical ingredient, known for its efficacy in targeting and inhibiting parasitic growth.
  • Versatility: Effective in treating toxoplasmosis, a significant concern for individuals with compromised immune systems, and in combination therapy for malaria.
  • Dosage Form: Comes in tablet form, making it easy to administer and incorporate into treatment regimens.
  • Targeted Action: Daraprim works by selectively inhibiting the replication of parasitic protozoa, offering relief and protection to patients suffering from these infections.
  • Improved Quality of Life: By effectively managing and treating infections like toxoplasmosis and malaria, patients can experience significant improvements in their health and well-being.
  • Compatibility: Daraprim can be used in combination with other medications, providing a comprehensive approach to treating complex parasitic infections.

How to Use Daraprim (Pyrimethamine)?

  • Take Daraprim exactly as prescribed by your doctor.
  • Only adjust your dose after consulting your healthcare provider.
  • Daraprim is taken orally.
  • Swallow the tablet whole with water. It can be taken with or without food. However, taking it with food may help reduce stomach upset.
  • If you have difficulty swallowing tablets, consult your healthcare provider for advice.
  • The dosage is based on your medical condition, response to treatment, and other medications you may be taking.
  • Be sure to inform your doctor about all the medications you use, including prescription drugs, nonprescription drugs, and herbal products.

Important Safety Information about Daraprim

  • Before taking Daraprim, inform your doctor about any allergies you have, and provide a complete list of medications you are taking, including prescription drugs, over-the-counter medications, and herbal products.
  • Pregnant or breastfeeding women should consult their healthcare provider before starting Daraprim due to potential risks to the baby.
  • Regular monitoring of blood tests may be required to check for side effects.

Fact Table for Daraprim

Generic Name Pyrimethamine
Brand Name
 		Daraprim
Classification Antiparasitic
Indications
 		Used to treat toxoplasmosis and as part of combination therapy for malaria.
FDA Approval Date Originally approved in 1953. (Note: Confirm current approval status as regulations may change.).
Mechanism of Action
 		Inhibits folic acid synthesis in parasites, preventing their growth and reproduction.
Administration Route Oral
Dosage Form Tablet
Common Side Effects Nausea, vomiting, loss of appetite, dizziness.
Serious Side Effects Bone marrow suppression, allergic reactions, severe rash.
Contraindications Known hypersensitivity to pyrimethamine or any component of the formulation.
Special Considerations – Requires careful dose adjustment in renal or hepatic impairment. – Potential risks during pregnancy and lactation need to be assessed by a healthcare provider.
Interactions May interact with other medications such as folate antagonists and certain anticonvulsants.
Storage Recommendations Store at room temperature away from light and moisture.
Prescription Required Yes
Monitoring Regular blood tests may be required to monitor for side effects.

Common Side Effects of Daraprim

Like all medications, Daraprim (Pyrimethamine) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Nausea
  • Vomiting
  • Loss of appetite
  • Dizziness

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Daraprim (Pyrimethamine)?

You can order Daraprim (Pyrimethamine) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. How does Daraprim work?

    Daraprim works by preventing parasites from producing necessary proteins, thus stopping their growth and reproduction within the body. It targets the parasites while sparing human cells, making it an effective treatment against infections like toxoplasmosis and malaria.

  2. What should be avoided while taking Daraprim?

    Patients should follow their doctor’s advice regarding any restrictions on food, beverages, or activity while taking Daraprim. It’s also crucial to avoid skipping doses or stopping the medication without your doctor’s approval, as this could increase parasite resistance and make the infection more difficult to treat.

  3. What if I miss a dose or overdose?

    If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. In the case of an overdose, seek emergency medical attention. Symptoms of overdose might include stomach pain, vomiting, or convulsions.

  4. Is it safe to breastfeed while taking Daraprim?

    Daraprim can pass into breast milk and may cause side effects in a nursing infant. Discuss with your doctor whether you should either discontinue the drug or stop breastfeeding.

  5. Can Daraprim be used during pregnancy?

    Daraprim should be used during pregnancy only if clearly needed and directed by a doctor due to potential risks to the unborn baby. In some cases, it’s given to pregnant women to treat toxoplasmosis after evaluating the risks and benefits.

  6. What are the common side effects of Daraprim?

    While Daraprim can be an effective treatment, it does come with potential side effects. Common issues include vomiting, loss of appetite, and in some cases, allergic reactions like hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. More serious side effects can include signs of blood problems (easy bruising or bleeding, high fever, severe tiredness), sore throat, and severe skin reactions. If you face any side effects, consult your doctor right away.

  7. How should Daraprim be taken?

    Daraprim should be taken by mouth, following your doctor’s instructions closely. It’s recommended to take this medication with food to decrease the likelihood of nausea and vomiting. Dosage is determined based on the infection being treated, the patient’s medical condition, age, and response to treatment. It’s crucial to maintain a constant level of the drug in your body for it to be most effective, so regular intake as prescribed by your doctor is important.

  8. What is Daraprim, and what does it treat?

    Daraprim, known by its generic name pyrimethamine, is an antiparasitic medication. It’s primarily used to treat toxoplasmosis, a serious infection caused by the Toxoplasma parasite. This condition can occur in the body, brain, or eyes and is particularly dangerous for people with HIV infection. Daraprim is also used to treat and prevent certain types of malaria, although it’s usually not the first choice for malaria prevention in travelers.

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Questions?

References
Daraprim [package insert].Research Triangle Park, NC: GlaxoSmithKline; 2003.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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