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Ocrevus (Ocrelizumab)

Ocrevus
Ocrelizumab
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Ocrevus (Ocrelizumab)

Ocrevus (Ocrelizumab) is a prescription medication used to treat multiple sclerosis (MS) in adults. It specifically targets B cells, a type of white blood cell involved in the abnormal immune response that damages the nervous system in MS. Ocrevus is effective in treating both relapsing forms of MS (RMS) and primary progressive MS (PPMS), helping to reduce the frequency of relapses and slow the progression of disability.

Why Choose Ocrevus (Ocrelizumab)?

  • Reduces Relapses: Significantly decreases the frequency of MS relapses.
  • Slows Disability Progression: Helps slow the worsening of physical disability in both RMS and PPMS.
  • Targets B Cells: Specifically targets and depletes B cells, which play a critical role in the disease process of MS.
  • Convenient Dosing: Administered via intravenous infusion every six months, reducing the frequency of treatments.

How to Use Ocrevus (Ocrelizumab)?

  • Consult Your Healthcare Provider: Discuss your medical history and any other medications you’re taking.
  • Pre-Medication: Your healthcare provider may give you medications before the infusion to reduce the risk of infusion reactions.
  • Infusion Administration: Ocrevus is administered by a healthcare professional via an IV infusion in a medical setting.
  • Monitoring: You will be monitored during and after the infusion for any adverse reactions.
  • Follow-Up: Schedule regular follow-up appointments with your healthcare provider to monitor your progress and manage any side effects.

Important Safety Information about Ocrevus

  • Allergic Reactions: Inform your healthcare provider if you have a history of severe allergic reactions.
  • Infections: Ocrevus can increase the risk of infections. Notify your healthcare provider immediately if you experience any signs of infection.
  • Vaccinations: Ensure you are up-to-date with all vaccinations before starting treatment, as certain vaccines should not be given during treatment with Ocrevus.
  • Breastfeeding and Pregnancy: Discuss the potential risks with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Fact Table

 

Facts Details
Generic Name Ocrelizumab
Brand Name Ocrevus
Indication Multiple Sclerosis (MS), including Relapsing MS (RMS) and Primary Progressive MS (PPMS)
Mechanism of Action Targets and depletes CD20-positive B cells involved in the abnormal immune response in MS
Administration Route Intravenous (IV) infusion
Dosage Frequency Every six months
Initial Dose 300 mg IV infusion, followed two weeks later by a second 300 mg IV infusion
Maintenance Dose 600 mg IV infusion every six months
Pre-Medication Required Yes, to reduce the risk of infusion reactions (e.g., corticosteroids, antihistamines)
Common Side Effects Infusion reactions, respiratory tract infections, herpes infections, skin reactions, fatigue
Contraindications Severe active infections, known active malignancies, known hypersensitivity to Ocrelizumab
Monitoring Requirements Regular monitoring during and after infusion for adverse reactions, periodic health evaluations

Common Side Effects

Like all medications, Ocrevus (Ocrelizumab) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Infusion Reactions
  • Infections
  • Skin Reactions
  • Fatigue

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Ocrevus (Ocrelizumab)?

You can order Ocrevus (Ocrelizumab) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. What is Ocrevus used for?

    Ocrevus is primarily used to treat multiple sclerosis (MS). It is effective in both relapsing forms of MS, including relapsing-remitting MS and active secondary progressive disease, as well as primary progressive MS.

  2. How does Ocrevus work?

    Ocrevus works by targeting a protein called CD20 on the surface of B cells, a type of white blood cell. It helps reduce inflammation and slows disease progression by destroying these cells, which are implicated in the damage caused by MS.

  3. What are the most common side effects of Ocrevus?

    Common side effects include infusion reactions, infections (such as respiratory and skin infections), and a possible increase in the risk of certain cancers, including breast cancer. It’s important to monitor for signs of serious infections and report them to a healthcare provider.

  4. How is Ocrevus administered?

    Ocrevus is given as an intravenous infusion. The first dose is divided into two infusions two weeks apart. Subsequent doses are given as a single infusion every six months.

  5. What should I do if I miss a dose of Ocrevus?

    If you miss a dose, contact your healthcare provider to reschedule it as soon as possible. It is important not to wait until the next scheduled dose. Future infusions should be spaced six months apart.

  6. Can Ocrevus affect pregnancy and breastfeeding?

    Ocrevus may pose risks during pregnancy and breastfeeding. Women should use effective contraception during treatment and for six months after the last dose. It is not known if Ocrevus is present in breast milk.

  7. What should I tell my healthcare provider before starting Ocrevus?

    Inform your healthcare provider about any infections, history of hepatitis B, recent vaccinations, and any other medications you are taking, especially those that affect the immune system.

  8. How long does it take for Ocrevus to work?

    Some effects, such as reduced relapse rates, can be seen within 12 weeks, but full benefits may take six months or longer to manifest.

  9. Can I receive vaccinations while on Ocrevus?

    Live vaccines should be avoided during treatment. Non-live vaccines should ideally be given at least two weeks before starting Ocrevus.

  10. Is Ocrevus a form of chemotherapy?

    No, Ocrevus is not chemotherapy. It is a monoclonal antibody that targets specific proteins on B cells and is used to treat MS by modulating the immune system.

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Questions?

References
Ocrevus (Ocrelizumab) [package insert].South San Francisco, CA: Genentech; 2022.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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